Cited 4 times in
[(18)F]FPEB and [(18)F]FDEGPECO comparative study of mGlu5 quantification in rodent brain
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 최재용 | - |
dc.date.accessioned | 2016-02-04T11:22:36Z | - |
dc.date.available | 2016-02-04T11:22:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0969-8043 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140288 | - |
dc.description.abstract | The aim of this study is to compare [(18)F]FPEB and [(18)F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [(18)F]FPEB PET showed higher brain uptake and superior binding potential values than those of [(18)F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [(18)F]FPEB and [(18)F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [(18)F]FPEB is >4 fold than those of [(18)F]FDEGPECO. From this evidence, we conclude that [(18)F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | APPLIED RADIATION AND ISOTOPES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain/diagnostic imaging* | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Corpus Striatum/diagnostic imaging | - |
dc.subject.MESH | Corpus Striatum/metabolism | - |
dc.subject.MESH | Fluorine Radioisotopes* | - |
dc.subject.MESH | Hippocampus/diagnostic imaging | - |
dc.subject.MESH | Hippocampus/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nitriles* | - |
dc.subject.MESH | Oximes* | - |
dc.subject.MESH | Positron-Emission Tomography/methods | - |
dc.subject.MESH | Pyridines* | - |
dc.subject.MESH | Radiopharmaceuticals* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptor, Metabotropic Glutamate 5/metabolism* | - |
dc.subject.MESH | Tissue Distribution | - |
dc.title | [(18)F]FPEB and [(18)F]FDEGPECO comparative study of mGlu5 quantification in rodent brain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jee Hae Kang | - |
dc.contributor.googleauthor | Minkyung Lee | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Kyo Chul Lee | - |
dc.contributor.googleauthor | Tae Hyun Choi | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.identifier.doi | 10.1016/j.apradiso.2015.01.025 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A01057 | - |
dc.relation.journalcode | J00206 | - |
dc.identifier.eissn | 1872-9800 | - |
dc.identifier.pmid | 25658029 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0969804315000263 | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | [(18)F]FDEGPECO | - |
dc.subject.keyword | [(18)F]FPEB | - |
dc.subject.keyword | mGlu5 | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 98 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 107 | - |
dc.identifier.bibliographicCitation | APPLIED RADIATION AND ISOTOPES, Vol.98 : 103-107, 2015 | - |
dc.identifier.rimsid | 50404 | - |
dc.type.rims | ART | - |
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