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[(18)F]FPEB and [(18)F]FDEGPECO comparative study of mGlu5 quantification in rodent brain

DC Field Value Language
dc.contributor.author류철형-
dc.contributor.author유영훈-
dc.contributor.author김철훈-
dc.contributor.author최재용-
dc.date.accessioned2016-02-04T11:22:36Z-
dc.date.available2016-02-04T11:22:36Z-
dc.date.issued2015-
dc.identifier.issn0969-8043-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140288-
dc.description.abstractThe aim of this study is to compare [(18)F]FPEB and [(18)F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [(18)F]FPEB PET showed higher brain uptake and superior binding potential values than those of [(18)F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [(18)F]FPEB and [(18)F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [(18)F]FPEB is >4 fold than those of [(18)F]FDEGPECO. From this evidence, we conclude that [(18)F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAPPLIED RADIATION AND ISOTOPES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBrain/diagnostic imaging*-
dc.subject.MESHBrain/metabolism*-
dc.subject.MESHCorpus Striatum/diagnostic imaging-
dc.subject.MESHCorpus Striatum/metabolism-
dc.subject.MESHFluorine Radioisotopes*-
dc.subject.MESHHippocampus/diagnostic imaging-
dc.subject.MESHHippocampus/metabolism-
dc.subject.MESHMale-
dc.subject.MESHNitriles*-
dc.subject.MESHOximes*-
dc.subject.MESHPositron-Emission Tomography/methods-
dc.subject.MESHPyridines*-
dc.subject.MESHRadiopharmaceuticals*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptor, Metabotropic Glutamate 5/metabolism*-
dc.subject.MESHTissue Distribution-
dc.title[(18)F]FPEB and [(18)F]FDEGPECO comparative study of mGlu5 quantification in rodent brain-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorJee Hae Kang-
dc.contributor.googleauthorMinkyung Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorKyo Chul Lee-
dc.contributor.googleauthorTae Hyun Choi-
dc.contributor.googleauthorJae Yong Choi-
dc.identifier.doi10.1016/j.apradiso.2015.01.025-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01333-
dc.contributor.localIdA02485-
dc.contributor.localIdA01057-
dc.relation.journalcodeJ00206-
dc.identifier.eissn1872-9800-
dc.identifier.pmid25658029-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0969804315000263-
dc.subject.keywordPET-
dc.subject.keyword[(18)F]FDEGPECO-
dc.subject.keyword[(18)F]FPEB-
dc.subject.keywordmGlu5-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume98-
dc.citation.startPage103-
dc.citation.endPage107-
dc.identifier.bibliographicCitationAPPLIED RADIATION AND ISOTOPES, Vol.98 : 103-107, 2015-
dc.identifier.rimsid50404-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
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