Pathophysiology after pancreaticoduodenectomy

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MeSH: Duodenum/metabolism ; Duodenum/physiopathology ; Duodenum/surgery* ; Energy Metabolism ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/metabolism ; Gastrointestinal Diseases/physiopathology* ; Gastrointestinal Motility ; Humans ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/physiopathology ; Pancreas/metabolism ; Pancreas/physiopathology ; Pancreas/surgery* ; Pancreaticoduodenectomy/adverse effects* ; Pancreaticoduodenectomy/mortality ; Risk Factors ; Time Factors ; Treatment Outcome

Keywords: Delayed gastric emptying ; Exocrine insufficiency ; Fatty liver ; Metabolic surgery ; Pancreaticoduodenectomy ; Postoperative pancreatic fistula

Abstract: Pancreaticoduodenectomy (PD) will result in removal of important multiorgans in upper intestinal tract and subsequently secondary physiologic change. In the past, surgeons just focused on the safety of surgical procedure; however, PD is regarded as safe and widely applied to treatment of periampullary lesions. Practical issues after PD, such as, effect of duodenectomy, metabolic surgery-like effect, alignment effect of gastrointestinal continuity, and non-alcoholic fatty liver disease were summarized and discussed.