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Serum monokine induced by gamma interferon as a novel biomarker for coronary artery calcification in humans

 Yu, Hee Tae  ;  Oh, Jaewon  ;  Chang, Hyuk-Jae  ;  Lee, Sang-Hak  ;  Shin, Eui-Cheol  ;  Park, Sungha 
 CORONARY ARTERY DISEASE, Vol.26(4) : 317-321, 2015 
Journal Title
Issue Date
Aged ; Biomarkers/blood* ; Chemokine CXCL9/blood* ; Coronary Artery Disease/blood* ; Coronary Artery Disease/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Vascular Calcification/blood* ; Vascular Calcification/diagnosis ; Substances ; Biomarkers ; CXCL9 protein, human ; Chemokine CXCL9
chemokine ; coronary artery calcium score ; monokine induced by gamma interferon
BACKGROUND: T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed. We aimed to examine the association between serum levels of the monokine induced by gamma interferon (MIG) and the coronary artery calcium score (CACS). METHODS: We enrolled 456 individuals (285 men, 66.5±5.8 years) who were registered in the Mapo-gu public health center cohort. We selected 228 individuals with a CACS of more than 100 and 228 age-matched and sex-matched individuals with a CACS of less than 100. All participants underwent coronary computed tomography for CACS measuring. Clinical and laboratory variables including serum MIG levels were analyzed at the time of enrollment. RESULTS: The serum level of MIG was significantly higher in participants with a CACS of more than 100 (152.1±119.1 vs. 130.3±112.9, P=0.046). Serum MIG levels correlated significantly with CACS (r=0.113, P=0.016), and higher levels of MIG were associated with severe plaque burden (CACS>400, P=0.025). Multiple linear regression analysis showed that serum MIG levels were associated independently with CACS after controlling for confounding factors and medications (β=0.114, P=0.026). CONCLUSION: Serum MIG levels were associated independently with CACS after adjusting for traditional cardiovascular risk factors. These findings suggest that MIG may be used as a novel biomarker for T-cell inflammation and atherosclerotic plaque burden in humans.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Yu, Hee Tae(유희태) ORCID logo https://orcid.org/0000-0002-6835-4759
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
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