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Pregnancy outcomes in women with moyamoya disease: experiences at a single center in Korea

 Yun Ji Jung  ;  Min-A Kim  ;  Ja-Young Kwon  ;  Hyo Ryun Lee  ;  Hee Young Cho  ;  Yong Won Park  ;  Young Han Kim 
 YONSEI MEDICAL JOURNAL, Vol.56(3) : 793-797, 2015 
Journal Title
Issue Date
Adult ; Blood Pressure/physiology ; Cesarean Section ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Maternal Age ; Moyamoya Disease/diagnosis* ; Moyamoya Disease/epidemiology ; Pregnancy ; Pregnancy Complications* ; Pregnancy Outcome/epidemiology* ; Republic of Korea/epidemiology ; Retrospective Studies
Moyamoya disease ; outcome ; pregnancy
PURPOSE: Moyamoya disease (MMD) occurs predominantly in Korean and Japanese women. The aim of this study was to investigate clinical features and pregnancy outcomes in women with MMD.
MATERIALS AND METHODS: We conducted a retrospective chart review of women with MMD who visited our Department of Obstetrics and Gynecology between January 2005 and October 2013. For all study subjects, clinical features, demographic characteristics, and perinatal outcomes were recorded.
RESULTS: We identified 28 pregnancies in 22 patients who had been diagnosed with MMD. The mean maternal age at delivery was 31.9±3.5 years old. The mean gestational age at delivery was 38.0±0.9 weeks. Among the 28 pregnancies, 25 (92.5%) underwent cesarean section; 19 (76.0%) of them were performed under regional anesthesia and six (24.0%) under general anesthesia. The mean newborn weight was 3233.7±348.2 g. The 5-minute Apgar score in 85% of the newborns was higher than 8, with no other apparent complications. During the puerperal period, transient ischemic attack symptom or seizure occurred in 4 cases, although patients recovered within a few days.
CONCLUSION: For pregnant women with MMD, it is important to control blood pressure and prevent hyperventilation during the intrapartum period, and the best methods of delivery and anesthesia should be considered to avoid unfavorable sequelae. Additionally, a multidisciplinary approach (i.e., neurosurgery) is necessary to constantly manage underlying diseases.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Min A(김민아)
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Lee, Hyo Ryun(이효련)
Jung, Yun Ji(정윤지) ORCID logo https://orcid.org/0000-0001-6615-6401
Cho, Hee Young(조희영)
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