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Clinical implications of angiotensin II type 1 receptor antibodies in antibody-mediated rejection without detectable donor-specific HLA antibodies after renal transplantation

DC FieldValueLanguage
dc.contributor.author김범석-
dc.contributor.author김유선-
dc.contributor.author김혜진-
dc.contributor.author박용정-
dc.contributor.author이재근-
dc.contributor.author이주한-
dc.contributor.author허규하-
dc.date.accessioned2016-02-04T11:17:13Z-
dc.date.available2016-02-04T11:17:13Z-
dc.date.issued2015-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140086-
dc.description.abstractBACKGROUND: Solid-phase immunoassays have improved detection sensitivity for donor-specific HLA antibody (DSHA) and permitted the accurate diagnosis of antibody-mediated rejection (AMR). However, DSHA is not always sufficient to explain the cause of AMR. Consequently, a means of assessing non-HLA antibodies is required to determine the cause of AMR. The aim of the present study was to evaluate the clinical implications of antibodies (Abs) targeting angiotensin II type I receptor (AT1R) in recipients with AMR but without serum DSHA. METHODS: Non-HLA AMR cases diagnosed between January 2011 and June 2014 were included. Levels of anti-AT1R Abs (U/mL) were quantified by using AT1R assay kits (One Lambda, Calif, United States) with collected sera pretransplantation and at biopsy (cut-off value: 15 U/mL). RESULTS: Seventy-two patients were diagnosed with AMR during the above-mentioned period. Of them, 12 recipients (16.7%) had no DSHA. The sera of these 12 patients were tested (2 patients were only checked at time of biopsy). Nine patients (9/10) were presensitized for anti-AT1R Abs (median, 25.0 U/mL; range, 12.9 to 50.0 U/mL). Ten patients (10/12) were anti-AT1R- positive at time of biopsy (median, 23.2 U/mL; range, 11.4 to 50.0 U/mL). The mean time from transplantation to biopsy was 73 months. Eight patients experienced acute AMR, and 4 developed chronic AMR. Four patients showed negative C4d staining in peritubular capillaries (4/12). Patients were treated with plasmapheresis, low-dose intravenous immunoglobulin, and/or rituximab. CONCLUSIONS: AT1R Abs may play a significant role in AMR without detectable DSHA. Pretransplantation detection of AT1R Abs may be helpful for assessing the risk for non-HLA AMR.-
dc.description.statementOfResponsibilityopen-
dc.format.extent649~652-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/blood-
dc.subject.MESHGraft Rejection/immunology*-
dc.subject.MESHHLA Antigens/blood-
dc.subject.MESHHLA Antigens/immunology*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoassay-
dc.subject.MESHIsoantibodies/blood-
dc.subject.MESHIsoantibodies/immunology*-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReceptor, Angiotensin, Type 1/blood-
dc.subject.MESHReceptor, Angiotensin, Type 1/immunology*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHYoung Adult-
dc.titleClinical implications of angiotensin II type 1 receptor antibodies in antibody-mediated rejection without detectable donor-specific HLA antibodies after renal transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJ. Lee-
dc.contributor.googleauthorY. Park-
dc.contributor.googleauthorB.S. Kim-
dc.contributor.googleauthorJ.G. Lee-
dc.contributor.googleauthorH.J. Kim-
dc.contributor.googleauthorY.S. Kim-
dc.contributor.googleauthorK.H. Huh-
dc.identifier.doi10.1016/j.transproceed.2014.11.055-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00488-
dc.contributor.localIdA00785-
dc.contributor.localIdA01582-
dc.contributor.localIdA03068-
dc.contributor.localIdA03163-
dc.contributor.localIdA04344-
dc.contributor.localIdA01181-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid25891704-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S004113451500144X-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameKim, Hye Jin-
dc.contributor.alternativeNamePark, Yong Jung-
dc.contributor.alternativeNameLee, Jae Geun-
dc.contributor.alternativeNameLee, Ju Han-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorPark, Yong Jung-
dc.contributor.affiliatedAuthorLee, Jae Geun-
dc.contributor.affiliatedAuthorLee, Ju Han-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Hye Jin-
dc.rights.accessRightsnot free-
dc.citation.volume47-
dc.citation.number3-
dc.citation.startPage649-
dc.citation.endPage652-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.47(3) : 649-652, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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