Clonal and horizontal spread of the blaOXA-232 gene among Enterobacteriaceae in a Korean hospital

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Authors: Seok Hoon Jeong ; Kyu Man Lee ; Jacob Lee ; Il Kwon Bae ; Jae-Seok Kim ; Han-Sung Kim ; Wonkeun Song

Citation: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.82(1) : 70-72, 2015

MeSH: Adult ; Aged ; Aged, 80 and over ; Conjugation, Genetic ; Cross Infection/microbiology* ; Electrophoresis, Gel, Pulsed-Field ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology* ; Escherichia coli/enzymology* ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Female ; Gene Transfer, Horizontal ; Genotype ; Hospitals ; Humans ; Klebsiella pneumoniae/classification ; Klebsiella pneumoniae/enzymology* ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Korea/epidemiology ; Male ; Middle Aged ; Molecular Epidemiology ; Molecular Typing ; Plasmids/analysis* ; beta-Lactamases/genetics* ; beta-Lactamases/secretion

Abstract: All 16 Klebsiella pneumoniae isolates and both Escherichia coli isolates harbored the bla(OXA-232) and bla(CTX-M-15) genes. Furthermore, all 16 K. pneumoniae isolates belonged to a unique pulsed-field gel electrophoresis clone and were assigned to an identical sequence type (ST14). The 2 E. coli isolates were identified as ST131 and ST457. The bla(OXA-232) gene underwent horizontal transfer to E. coli isolates via a conjugative ColE-type plasmid. The introduction of this K. pneumoniae ST14 strain to the Korean hospital was attributed to an index patient who was likely colonized during a prior hospitalization in India.

Full Text: http://www.sciencedirect.com/science/article/pii/S0732889315000358

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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