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Clinical assessment of lipid profiles in live kidney donors

 Y.E. Yoon  ;  K.H. Choi  ;  K.H. Kim  ;  S.C. Yang  ;  W.K. Han 
 TRANSPLANTATION PROCEEDINGS, Vol.47(3) : 584-587, 2015 
Journal Title
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Adult ; Cholesterol/blood ; Dyslipidemias/blood ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation* ; Lipids/blood* ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Living Donors* ; Logistic Models ; Male ; Middle Aged ; Nephrectomy* ; Odds Ratio ; Postoperative Period ; Renal Insufficiency, Chronic/blood ; Triglycerides/blood
BACKGROUND: Abnormal serum lipid profiles are an issue in chronic kidney disease (CKD), but the clinical ramifications of dyslipidemia in live kidney donors are unclear. Thus, we explored the relationship between serum lipids and residual renal function in living donors post-nephrectomy. METHODS: Charts of living donors who underwent nephrectomy between January 2010 and March 2013 were reviewed, targeting those with 6-month follow-up examinations at minimum. Altogether, 282 donors were studied, examining total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels assayed before donation by standard techniques. Median follow-up time was 14 months. The relationship between postoperative renal function and allograft biopsy results was assessed. Recursive partitioning was applied to identify optimal cut-off points for each parameter. RESULTS: Median (interquartile range) serum TC, TG, LDL, and HDL levels were 183 (161-205) mg/dL, 86 (63-131) mg/dL, 108 (92-128) mg/dL, and 53 (44-62) mg/dL, respectively. The glomerular filtration rate at last follow-up was associated with TC (r = -0.187; P = .002) and LDL (r = -0.172; P = .005) levels, but showed no correlation with TG and HDL. Root nodes of TC and LDL determinations in recursive partitioning were 170.5 mg/dL and 80.5 mg/dL, respectively, serving as thresholds for further evaluation. On logistic regression analysis, the likelihood of CKD (glomerular filtration rate < 60 mL/min/1.73 m(2)) at last follow-up was greater in donors with elevated TC and LDL levels (odds ratio = 1.96 and 3.33; P = .021 and .029, respectively). CONCLUSION: Kidney donors with serum TC and LDL elevations require close observation, given their demonstrable predisposition to CKD after donation.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Hyun(김광현)
Yang, Seung Choul(양승철)
Yoon, Young Eun(윤영은)
Choi, Kyung Hwa(최경화)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
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