Cited 6 times in
Clinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 공훈영 | - |
dc.contributor.author | 임종백 | - |
dc.date.accessioned | 2016-02-04T11:13:33Z | - |
dc.date.available | 2016-02-04T11:13:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139946 | - |
dc.description.abstract | AIM: To evaluate the clinical usefulness of soluble heparin-binding epidermal growth factor (sHB-EGF) as a serum biomarker for gastric cancer (GC). METHODS: Serum sHB-EGF levels were measured by a commercially available human HB-EGF ELISA Kit and compared among 60 normal controls, 30 high-risk patients, 37 early gastric cancer (EGC), and 30 advanced gastric cancer (AGC) through ANOVA test. Correlations between serum sHB-EGF and clinicopathological features of GC were analyzed through Spearman's correlation. The diagnostic performance of serum sHB-EGF for GC was evaluated through receiver operating characteristic (ROC) curve and logistic regression analysis. RESULTS: Serum sHB-EGF levels were significantly higher in AGC group (314.4±127.5 pg/mL) than EGC (165.3±123.2 pg/mL), high-risk (98.7±67.3 pg/mL), and control (94.7±83.6 pg/mL) groups (post-hoc Bonferroni, all P<0.001), respectively. Serum sHB-EGF levels were also significantly higher in EGC group than high-risk (P=0.049) and control (P=0.006) groups. Clinicopathologically, serum sHB-EGF levels closely correlated with depth of invasion (T-stage, γs=0.669, P<0.001), lymph node metastasis (N-stage, γs=0.407, P=0.001), and distant metastasis (M-stage, γs=0.261, P=0.030). ROC curve and logistic regression analysis demonstrated a remarkable diagnostic potential of serum sHB-EGF. CONCLUSION: Serum sHB-EGF is closely correlated with advanced stage GC and can be a promising serological biomarker for GC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2080~2088 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Biomarkers, Tumor/blood* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heparin-binding EGF-like Growth Factor/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Stomach Neoplasms/blood* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.title | Clinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Hye Won Chung | - |
dc.contributor.googleauthor | Hoon Young Kong | - |
dc.contributor.googleauthor | Jong-Baeck Lim | - |
dc.identifier.doi | 10.3748/wjg.v21.i7.2080 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00164 | - |
dc.contributor.localId | A03403 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 25717241 | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | Diagnostic | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Prognostic | - |
dc.subject.keyword | Soluble heparin-binding EGF-like growth facto | - |
dc.contributor.alternativeName | Kong, Hoon Young | - |
dc.contributor.alternativeName | Lim, Jong Baeck | - |
dc.contributor.affiliatedAuthor | Kong, Hoon Young | - |
dc.contributor.affiliatedAuthor | Lim, Jong Baeck | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2080 | - |
dc.citation.endPage | 2088 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.21(7) : 2080-2088, 2015 | - |
dc.identifier.rimsid | 48398 | - |
dc.type.rims | ART | - |
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