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Clinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer

DC FieldValueLanguage
dc.contributor.author공훈영-
dc.contributor.author임종백-
dc.date.accessioned2016-02-04T11:13:33Z-
dc.date.available2016-02-04T11:13:33Z-
dc.date.issued2015-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139946-
dc.description.abstractAIM: To evaluate the clinical usefulness of soluble heparin-binding epidermal growth factor (sHB-EGF) as a serum biomarker for gastric cancer (GC). METHODS: Serum sHB-EGF levels were measured by a commercially available human HB-EGF ELISA Kit and compared among 60 normal controls, 30 high-risk patients, 37 early gastric cancer (EGC), and 30 advanced gastric cancer (AGC) through ANOVA test. Correlations between serum sHB-EGF and clinicopathological features of GC were analyzed through Spearman's correlation. The diagnostic performance of serum sHB-EGF for GC was evaluated through receiver operating characteristic (ROC) curve and logistic regression analysis. RESULTS: Serum sHB-EGF levels were significantly higher in AGC group (314.4±127.5 pg/mL) than EGC (165.3±123.2 pg/mL), high-risk (98.7±67.3 pg/mL), and control (94.7±83.6 pg/mL) groups (post-hoc Bonferroni, all P<0.001), respectively. Serum sHB-EGF levels were also significantly higher in EGC group than high-risk (P=0.049) and control (P=0.006) groups. Clinicopathologically, serum sHB-EGF levels closely correlated with depth of invasion (T-stage, γs=0.669, P<0.001), lymph node metastasis (N-stage, γs=0.407, P=0.001), and distant metastasis (M-stage, γs=0.261, P=0.030). ROC curve and logistic regression analysis demonstrated a remarkable diagnostic potential of serum sHB-EGF. CONCLUSION: Serum sHB-EGF is closely correlated with advanced stage GC and can be a promising serological biomarker for GC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2080~2088-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHArea Under Curve-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHeparin-binding EGF-like Growth Factor/blood*-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHROC Curve-
dc.subject.MESHStomach Neoplasms/blood*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.titleClinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorHye Won Chung-
dc.contributor.googleauthorHoon Young Kong-
dc.contributor.googleauthorJong-Baeck Lim-
dc.identifier.doi10.3748/wjg.v21.i7.2080-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00164-
dc.contributor.localIdA03403-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid25717241-
dc.subject.keywordBiomarker-
dc.subject.keywordDiagnostic-
dc.subject.keywordGastric cancer-
dc.subject.keywordPrognostic-
dc.subject.keywordSoluble heparin-binding EGF-like growth facto-
dc.contributor.alternativeNameKong, Hoon Young-
dc.contributor.alternativeNameLim, Jong Baeck-
dc.contributor.affiliatedAuthorKong, Hoon Young-
dc.contributor.affiliatedAuthorLim, Jong Baeck-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number7-
dc.citation.startPage2080-
dc.citation.endPage2088-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.21(7) : 2080-2088, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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