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Three cases of pruritic urticarial papules and plaques of pregnancy (PUPPP) treated with intramuscular injection of autologous whole blood

Authors
 I K Jeon  ;  H R On  ;  S H Oh  ;  S K Hann 
Citation
 JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, Vol.29(4) : 797-800, 2015 
Journal Title
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
ISSN
 0926-9959 
Issue Date
2015
MeSH
Adult ; Blood Transfusion, Autologous/methods* ; Female ; Humans ; Injections, Intramuscular ; Pregnancy ; Pregnancy Complications/therapy* ; Pruritus/therapy* ; Retrospective Studies
Abstract
BACKGROUND: Pruritic urticarial papules and plaques of pregnancy (PUPPP), also known as polymorphic eruption of pregnancy, is a common and benign but exceedingly uncomfortable dermatosis of pregnancy. Investigation of new treatment options has been limited by patient concerns about the negative fetal effects of medication.
OBJECTIVE: To assess the efficacy of intramuscular injection of autologous whole blood (AWB) for treatment of PUPPP.
METHODS: This is a retrospective descriptive case series of three patients with PUPPP, all of whom were treated with intramuscular injection of AWB.
RESULTS: All patients showed good responses to intramuscular injection of AWB, tolerated the treatment, and there were no adverse effects to the patients or their babies.
CONCLUSION: AWB may be an alternative treatment option for patients with PUPPP who are worried about the risk of medication use during pregnancy or breastfeeding. Whole blood collected from the patient's own body may be preferable to foreign medications. Future investigation into the exact mechanism with controlled clinical studies using a large number of patients will be necessary to provide supporting evidence for this potential treatment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jdv.12414/abstract
DOI
10.1111/jdv.12414
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139880
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