Cited 27 times in
Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Korea
DC Field | Value | Language |
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dc.contributor.author | 이경원 | - |
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 홍준성 | - |
dc.date.accessioned | 2016-02-04T11:11:41Z | - |
dc.date.available | 2016-02-04T11:11:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2093-2340 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139876 | - |
dc.description.abstract | BACKGROUND: The aim of this study was to investigate the molecular epidemiological characteristics of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clinical isolates in Korea. MATERIALS AND METHODS: Three hundred and twenty nine P. aeruginosa clinical isolates were collected from 23 general hospitals in Korea from March to June 2014. Species were identified by matrix-assited laser desorption/ionization-time of flight and 16S rRNA sequencing. Antimicrobial susceptibility was determined by disk diffusion methods. Further, minimum inhibitory concentrations of carbapenems were determined by Etest. Polymerase chain reaction and sequencing were performed to identify genes encoding MBLs. Multi-locus sequence typing and pulsed-field gel electrophoresis were performed to determine epidemiological characteristics of MBL-producing P. aeruginosa isolates. RESULTS: Of the 329 isolates, 229 (69.6%) were susceptible to the carbapenems tested, including imipenem and meropenem; while 100 (30.4%) were non-susceptible to more than one of the carbapenems. Genes encoding imipenemase-6 (IMP-6) and Verona imipenemase-2 (VIM-2) MBLs were identified in 21 (6.4%) isolates (n = 17 and 4, respectively). All MBL-producing isolates showed multi-drug resistant phenotype, and a majority (n = 19) of the isolates were identified as sequence type 235 (ST235). The remaining isolates (n = 2) were identified as ST309 and ST463. CONCLUSION: P. aeruginosa ST235 might play an important role in dissemination of MBL genes in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33~40 | - |
dc.relation.isPartOf | INFECTION AND CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jun Sung Hong | - |
dc.contributor.googleauthor | Jung Ok Kim | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Il Kwon Bae | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.identifier.doi | 10.3947/ic.2015.47.1.33 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03619 | - |
dc.contributor.localId | A04438 | - |
dc.relation.journalcode | J01053 | - |
dc.identifier.eissn | 2092-6448 | - |
dc.identifier.pmid | 25844261 | - |
dc.subject.keyword | International clone | - |
dc.subject.keyword | Multi-locus sequence typing | - |
dc.subject.keyword | Pseudomonas aeruginosa | - |
dc.subject.keyword | VIM-2 metallo-β-lactamase | - |
dc.subject.keyword | metallo-β-lactamase | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.alternativeName | Hong, Jun Sung | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Jun Sung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 40 | - |
dc.identifier.bibliographicCitation | INFECTION AND CHEMOTHERAPY, Vol.47(1) : 33-40, 2015 | - |
dc.identifier.rimsid | 46613 | - |
dc.type.rims | ART | - |
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