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The effects of aerobic exercise training on serum osteocalcin, adipocytokines and insulin resistance on obese young males

Authors
 Yu-Sik Kim  ;  Ji Sun Nam  ;  Dong-Wook Yeo  ;  Kyung Rae Kim  ;  Sang-Hoon Suh  ;  Chul Woo Ahn 
Citation
 CLINICAL ENDOCRINOLOGY, Vol.82(5) : 686-694, 2015 
Journal Title
 CLINICAL ENDOCRINOLOGY 
ISSN
 0300-0664 
Issue Date
2015
MeSH
Adipokines/blood* ; Adiposity ; Adult ; Body Mass Index ; Cross-Sectional Studies ; Energy Metabolism ; Exercise* ; Humans ; Insulin Resistance* ; Leptin/blood ; Male ; Obesity/blood* ; Osteocalcin/blood* ; Prospective Studies ; Young Adult
Abstract
OBJECTIVE: Osteocalcin has been proposed to be a novel link between bone and energy metabolism. Previous studies showed its relations to exercise, body fat and glucose metabolism, but their interrelationship remains inconslusive. We evaluated the changes in osteocalcin level following 8-week exercise programme and assessed how they are related to concomitant changes in body fat composition, insulin resistance and various adipocytokines in a single centre, randomized and prospective design. STUDY DESIGN AND METHODS: A total of 39 young obese, otherwise healthy males were randomly assigned to control (n = 10) and exercise (n = 29) groups. Subjects in Exercise group were on 8-week supervised exercise training programme of four sessions per week. Body fat compositions were analysed using whole body bone mineral density, various metabolic parameters, osteocalcin and adipocytokines were assessed from fasting blood samples before and after 8-week exercise programme. RESULTS: Body fat reduction following exercise significantly increased serum total (1·51 ± 0·36 vs 1·69 ± 0·39 mmol/l, P = 0·01, baseline vs postexercise) and undercarboxylated osteocalcin level (0·44 ± 0·14 vs 0·64 ± 0·26 mmol/l, P < 0·01), and the increase in osteocalcin was in negative correlations with changes in body weight, BMI and body fat percentage as well as HOMA-IR and leptin (all P < 0·05). The changes in osteocalcin and leptin were not independent predictors of changes in insulin resistance and osteocalcin, respectively. CONCLUSIONS: In a physiological axis of bone-fat-energy metabolism, exercise-induced body fat reduction and improved insulin sensitivity were accompanied by an increase in serum osteocalcin and leptin levels, but other factors also seem to be involved in this interrelationship.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/cen.12601/abstract
DOI
10.1111/cen.12601
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139857
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