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Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: a Korean national survey

Authors
 Sang Hoon Lee  ;  Dong Soon Kim  ;  Young Whan Kim  ;  Man Pyo Chung  ;  Soo Taek Uh  ;  Choon Sik Park  ;  Sung Hwan Jeong  ;  Yong Bum Park  ;  Hong Lyeol Lee  ;  Jeong Sup Song  ;  Jong Wook Shin  ;  Nam Soo Yoo  ;  Eun Joo Lee  ;  Jin Hwa Lee  ;  Yangin Jegal  ;  Hyun Kyung Lee  ;  Moo Suk Park 
Citation
 CHEST, Vol.147(2) : 465-474, 2015 
Journal Title
 CHEST 
ISSN
 0012-3692 
Issue Date
2015
MeSH
Aged ; Ailanthus ; Dust* ; Humans ; Idiopathic Pulmonary Fibrosis/complications ; Idiopathic Pulmonary Fibrosis/epidemiology* ; Idiopathic Pulmonary Fibrosis/physiopathology ; Lung Neoplasms/complications ; Lung Neoplasms/mortality ; Middle Aged ; Occupational Diseases/epidemiology* ; Occupational Exposure* ; Prognosis ; Respiratory Function Tests ; Respiratory Insufficiency/complications ; Respiratory Insufficiency/mortality ; Survival Analysis
Abstract
BACKGROUND: Previous studies have investigated the relationship between occupational and environmental agents and idiopathic pulmonary fibrosis (IPF). However, there have been few studies regarding the prognosis of patients with IPF according to patient occupation. METHODS: We investigated whether occupational dust exposure was associated with clinically decreased lung function and poor prognosis. The Korean Interstitial Lung Disease Research Group conducted a national survey to evaluate the clinical, physiologic, radiologic, and survival characteristics of patients with IPF. A total of 1,311 patients with IPF were stratified into five groups according to their occupation: (1) unemployed or homemakers (n = 628); (2) farmers, fishers, or ranchers (n = 230); (3) sales or service personnel (n = 131); (4) clerical or professional personnel (n = 151); and (5) specific dust-exposed workers (n = 171). RESULTS: The mean age of subjects at diagnosis, was 67.5 ± 9.7 years. Current smokers were 336 patients, 435 were exsmokers, and 456 were never smokers. Dust-exposed workers showed early onset of IPF (61.3 ± 8.6 years; P < .001) and a longer duration of symptoms at diagnosis (17.0 ± 28.2 months; P = .004). Aging (P = .001; hazard ratio [HR], 1.034; 95% CI, 1.014-1.054), FVC % predicted at diagnosis (P = .004; HR, 0.984; 95% CI, 0.974-0.995), and dust-exposure occupation (P = .033; HR, 1.813; 95% CI, 1.049-3.133) were associated with mortality. CONCLUSIONS: These findings indicate that occupational dust may be an aggravating factor associated with a poor prognosis in IPF.
Full Text
http://journal.publications.chestnet.org/article.aspx?articleid=1911734
DOI
10.1378/chest.14-0994
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Lee, Sang Hoon(이상훈) ORCID logo https://orcid.org/0000-0002-7706-5318
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139738
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