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The balancing act of GABAergic synapse organizers

Authors
 Jaewon Ko  ;  Gayoung Choii  ;  Ji Won Um 
Citation
 TRENDS IN MOLECULAR MEDICINE, Vol.21(4) : 256-268, 2015 
Journal Title
 TRENDS IN MOLECULAR MEDICINE 
ISSN
 1471-4914 
Issue Date
2015
MeSH
Animals ; Brain/physiology* ; Disease Models, Animal ; GABA Agents/pharmacology* ; Humans ; Neurons/drug effects ; Neurons/physiology ; Synapses/physiology* ; Synaptic Transmission ; gamma-Aminobutyric Acid/physiology*
Keywords
inhibitory synapse ; GABA ; synaptic adhesion ; excitation–inhibition balance ; synapse organizer
Abstract
GABA (γ-aminobutyric acid) is the main neurotransmitter at inhibitory synapses in the mammalian brain. It is essential for maintaining the excitation and inhibition (E/I) ratio, whose imbalance underlies various brain diseases. Emerging information about inhibitory synapse organizers provides a novel molecular framework for understanding E/I balance at the synapse, circuit, and systems levels. This review highlights recent advances in deciphering these components of the inhibitory synapse and their roles in the development, transmission, and circuit properties of inhibitory synapses. We also discuss how their dysfunction may lead to a variety of brain disorders, suggesting new therapeutic strategies based on balancing the E/I ratio.
Full Text
http://www.sciencedirect.com/science/article/pii/S1471491415000180
DOI
10.1016/j.molmed.2015.01.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Um, Ji Won(엄지원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139696
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