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Cited 26 times in

Catabolic metabolism during cancer EMT

Authors
 Yong Hoon Cha  ;  Jong In Yook  ;  Hyun Sil Kim  ;  Nam Hee Kim 
Citation
 ARCHIVES OF PHARMACAL RESEARCH, Vol.38(3) : 313-320, 2015 
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
 0253-6269 
Issue Date
2015
MeSH
Cell Survival/physiology ; Energy Metabolism/physiology* ; Epithelial-Mesenchymal Transition/physiology* ; Glucose/metabolism ; Glycolysis/physiology ; Humans ; Mitochondria/metabolism ; Neoplasm Metastasis ; Neoplasms/metabolism* ; Neoplasms/pathology ; Oxidative Phosphorylation ; Stress, Physiological/physiology
Keywords
Epithelial–mesenchymal transition (EMT) ; Catabolism ; Cancer ; Survival
Abstract
Aerobic glycolysis is widely accepted as the glucose metabolism for production of biomass such as nucleotides, amino acids, and fatty acids which underlie the anabolic process of cancer cell proliferation. The epithelial-mesenchymal transition (EMT) is a complex cellular mechanism for invasion and metastatic progression in cancer cells. While Snail-mediated EMT regulated by major oncogenic signaling has been well-studied over the last decade, metabolic reprogramming during the EMT has not. In this work, we emphasize the importance of catabolic metabolism for cancer cell survival during cancer cell EMT. Because specific catabolic processes such as autophage and fatty acid oxidation have been well explained, we mainly focus on the general aspects of energy metabolism promoting cancer cell survival under metabolic stress. We also revisit the role of mitochondria in catabolism as oxidative phosphorylation in cancer has long been underestimated. Considering the highly inefficient process of metastatic progression and profound metabolic stress following matrix detachment of solid cancer, catabolic reprogramming during the EMT may play an important role in overcoming metastatic inefficiency of cancer cells.
Full Text
http://link.springer.com/article/10.1007%2Fs12272-015-0567-x
DOI
10.1007/s12272-015-0567-x
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Hee(김남희) ORCID logo https://orcid.org/0000-0002-3087-5276
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Cha, Yong Hoon(차용훈) ORCID logo https://orcid.org/0000-0003-1761-3260
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139681
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