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Pandemic influenza A vaccination and incidence of Guillain-Barré syndrome in Korea

Authors
 Changsoo Kim  ;  Seonkyeong Rhie  ;  Mina Suh  ;  Dae Ryong Kang  ;  Yoon Jung Choi  ;  Geun-Ryang Bae  ;  Young-Chul Choi  ;  Byung Yool Jun  ;  Joon Soo Lee 
Citation
 Vaccine, Vol.33(15) : 1815-1823, 2015 
Journal Title
 Vaccine 
ISSN
 0264-410X 
Issue Date
2015
Abstract
BACKGROUND: Many studies have investigated the association between Guillain-Barré syndrome (GBS) and vaccinations during the influenza A H1N1 pandemic of 2009 (pH1N1). Based on a nationally representative sample, we estimated the incidence of GBS during the pandemic period in Korea. MATERIALS AND METHODS: All medical records of GBS cases were reviewed in 28 randomly selected hospitals during 2008-2010, and the number of GBS cases at the national level was extrapolated using emergency care utilization data. The GBS rate per 100,000 person-years was estimated in the reference and pandemic periods. RESULTS: The incidence of GBS was 0.63 (95% CI: 0.37-0.89) per 100,000 person-years in the reference period and 0.87 (0.49-1.26) in the pandemic period. During the vaccination season, the pandemic period GBS incidence rate was not significantly higher than the reference period incidence rate (rate ratio: 1.52; 0.99-2.32), but difference was observed among persons aged 20-34 years. Rate of GBS increased after pH1N1 vaccination compared to the reference period (1.46, 1.26-1.68). DISCUSSION: The incidence of GBS increased slightly but not significantly during the pandemic period, although pH1N1 vaccination increased the GBS rate. Therefore, mass influenza vaccination programs should not be precluded on the basis of GBS.
Full Text
http://www.sciencedirect.com/science/article/pii/S0264410X15002248
DOI
10.1016/j.vaccine.2015.02.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
강대용(Kang, Dae Ryong)
김창수(Kim, Chang Soo) ORCID logo https://orcid.org/0000-0002-5940-5649
이준수(Lee, Joon Soo) ORCID logo https://orcid.org/0000-0001-9036-9343
전병율(Jun, Byung Yool)
최영철(Choi, Young Chul) ORCID logo https://orcid.org/0000-0001-5525-6861
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139670
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