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Pandemic influenza A vaccination and incidence of Guillain-Barré syndrome in Korea

 Changsoo Kim  ;  Seonkyeong Rhie  ;  Mina Suh  ;  Dae Ryong Kang  ;  Yoon Jung Choi  ;  Geun-Ryang Bae  ;  Young-Chul Choi  ;  Byung Yool Jun  ;  Joon Soo Lee 
 VACCINE, Vol.33(15) : 1815-1823, 2015 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Female ; Guillain-Barre Syndrome/epidemiology* ; Guillain-Barre Syndrome/etiology* ; Humans ; Incidence ; Influenza A Virus, H1N1 Subtype/immunology* ; Influenza Vaccines/adverse effects* ; Influenza, Human/epidemiology* ; Influenza, Human/prevention & control ; Male ; Mass Vaccination/adverse effects* ; Middle Aged ; Pandemics ; Population Surveillance ; Republic of Korea/epidemiology ; Young Adult
Guillain–Barré syndrome ; Incidence rate ; Influenza ; Vaccination
BACKGROUND: Many studies have investigated the association between Guillain-Barré syndrome (GBS) and vaccinations during the influenza A H1N1 pandemic of 2009 (pH1N1). Based on a nationally representative sample, we estimated the incidence of GBS during the pandemic period in Korea. MATERIALS AND METHODS: All medical records of GBS cases were reviewed in 28 randomly selected hospitals during 2008-2010, and the number of GBS cases at the national level was extrapolated using emergency care utilization data. The GBS rate per 100,000 person-years was estimated in the reference and pandemic periods. RESULTS: The incidence of GBS was 0.63 (95% CI: 0.37-0.89) per 100,000 person-years in the reference period and 0.87 (0.49-1.26) in the pandemic period. During the vaccination season, the pandemic period GBS incidence rate was not significantly higher than the reference period incidence rate (rate ratio: 1.52; 0.99-2.32), but difference was observed among persons aged 20-34 years. Rate of GBS increased after pH1N1 vaccination compared to the reference period (1.46, 1.26-1.68). DISCUSSION: The incidence of GBS increased slightly but not significantly during the pandemic period, although pH1N1 vaccination increased the GBS rate. Therefore, mass influenza vaccination programs should not be precluded on the basis of GBS.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Dae Ryong(강대용)
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
Jun, Byung Yool(전병율)
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
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