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Association of metabolic syndrome with coronary atherosclerosis in non-diabetic postmenopausal women

Authors
 B. H. Yun  ;  S. J. Chon  ;  Y. J. Lee  ;  E. J. Han  ;  S. Cho  ;  Y. S. Choi  ;  B. S. Lee  ;  S. K. Seo 
Citation
 CLIMACTERIC, Vol.18(2) : 284-289, 2015 
Journal Title
 CLIMACTERIC 
ISSN
 1369-7137 
Issue Date
2015
MeSH
Blood Glucose/analysis ; Body Mass Index ; Brachial Artery ; Cholesterol, HDL/blood ; Coronary Artery Disease/etiology* ; Coronary Artery Disease/physiopathology ; Fasting ; Female ; Humans ; Metabolic Syndrome/complications* ; Metabolic Syndrome/physiopathology ; Middle Aged ; Postmenopause* ; Pulse Wave Analysis ; Risk Factors ; Triglycerides/blood ; Vascular Stiffness
Keywords
ARTERIAL STIFFNESS ; CORONARY ATHEROSCLEROSIS ; METABOLIC SYNDROME ; POSTMENOPAUSAL WOMEN
Abstract
OBJECTIVE: We investigated the possible association of metabolic syndrome with arterial stiffness and coronary atherosclerosis in non-diabetic, postmenopausal women. METHODS: A total of 293 non-diabetic, postmenopausal women who visited the health promotion center for a routine health check-up were included in a cross-sectional study. Arterial stiffness was measured by brachial-ankle pulse wave velocity, and coronary atherosclerosis was detected using 64-row multi-detector computed tomography. RESULTS: Women with coronary atherosclerosis had a significantly higher proportion of metabolic syndrome than those without coronary atherosclerosis. The brachial-ankle pulse wave velocity was significantly higher in women who had metabolic syndrome compared to those who had no metabolic syndrome (1567.71 ± 211.81 vs. 1336.75 ± 159.62 cm/s, p < 0.001). In addition, the brachial-ankle pulse wave velocity was shown to increase with increasing number of metabolic syndrome components (p for trend < 0.001). Metabolic syndrome was associated with increased risk of coronary atherosclerosis (adjusted odds ratio 2.38; 95% confidence interval 1.01-5.06), after adjusting for confounding factors. CONCLUSIONS: Metabolic syndrome increases the risk of coronary atherosclerosis in postmenopausal women. Increased arterial stiffness may partly explain an increased risk of coronary atherosclerosis in postmenopausal women with metabolic syndrome.
Full Text
http://www.tandfonline.com/doi/full/10.3109/13697137.2014.960384
DOI
10.3109/13697137.2014.960384
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Lee, Yoo Jin(이유진)
Chon, Seung Joo(전승주)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
Han, E Jung(한이정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139639
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