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p53 expression as a prognostic factor in upper urinary tract urothelial carcinoma: a systematic review and meta-analysis

 Lee J.Y.  ;  Cho K.S.  ;  Diaz R.R.  ;  Choi Y.D.  ;  Choi H.Y. 
 UROLOGIA INTERNATIONALIS, Vol.94(1) : 50-57, 2015 
Journal Title
Issue Date
Biomarkers, Tumor/analysis* ; Carcinoma/chemistry* ; Carcinoma/pathology ; Chi-Square Distribution ; Female ; Humans ; Male ; Neoplasm Grading ; Neoplasm Staging ; Odds Ratio ; Predictive Value of Tests ; Risk Factors ; Sex Factors ; Tumor Suppressor Protein p53/analysis* ; Up-Regulation ; Urologic Neoplasms/chemistry* ; Urologic Neoplasms/pathology ; Urothelium/chemistry* ; Urothelium/pathology
Transitional cell carcinoma ; Kidney neopla는 ; Ureteral neoplasmsp53 genes ; Meta-analysis
OBJECTIVE: To conduct a meta-analysis examining p53 expression as a potential risk factor in upper urinary tract urothelial carcinoma (UUT-UC) and to systematically review the available data. METHODS: A comprehensive literature review was performed from January 1991 to August 2012, using search engines such as PubMed, EMBASE, Cochrane Library and KoreaMed. All retrieved references were manually reviewed, and two authors independently extracted the data. The quality of case-control and cohort studies was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) checklists. Heterogeneity among studies was examined using the Q statistics and Higgins' I(2) statistic. RESULTS: Of 302 abstracts of original research studies, nine case-control trials fit our criteria for inclusion in the analysis. Of the nine articles included, four scored 'low' and five scored 'modest' in the quality assessment performed according to the SIGN checklists. Analysis of the correlation between different factors and p53 expression in UUT-UC showed that pathologic stage (≥pT3 or <pT3) differed significantly between the p53 and non-p53 groups (OR = 2.720, p < 0.001). Statistically significant correlations were also detected between p53 expression and histologic grade (OR = 4.507, p < 0.001) and female gender (OR = 2.724, p < 0.001). CONCLUSION: The results of our meta-analysis suggest that p53 expression in UUT-UC was correlated with advanced pathologic stage, high histologic grade and female gender.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Joo Yong(이주용) ORCID logo https://orcid.org/0000-0002-3470-1767
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
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