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Randomized comparison of stent strut coverage following angiography- or optical coherence tomography-guided percutaneous coronary intervention

 Jung-Sun Kim  ;  Dong-Ho Shin  ;  Byeong-Keuk Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
 REVISTA ESPANOLA DE CARDIOLOGIA, Vol.68(3) : 190-197, 2015 
Journal Title
Issue Date
Coronary Angiography/methods* ; Coronary Artery Disease/diagnosis* ; Coronary Artery Disease/surgery ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/methods* ; Prospective Studies ; Prosthesis Design ; Sirolimus/analogs & derivatives* ; Sirolimus/pharmacology ; Surgery, Computer-Assisted/methods* ; Time Factors ; Tomography, Optical Coherence/methods* ; Treatment Outcome
Coronary disease ; Drug-eluting stent ; Enfermedad coronaria ; Optical coherence tomography ; Stent liberador de fármaco ; Tomografía de coherencia óptica
INTRODUCTION AND OBJECTIVES: The clinical benefits of optical coherence tomography-guided percutaneous coronary intervention are unclear. Therefore, in this study we sought to evaluate the impact of optical coherence tomography guidance on stent strut coverage following drug-eluting stent implantation. METHODS: A total of 101 patients in 105 lesions were randomly assigned to receive percutaneous coronary intervention under either optical coherence tomography guidance (n = 51 lesions of 50 patients) or angiography guidance (n = 54 lesions of 51 patients), and underwent a follow-up optical coherence tomography examination 6 months after zotarolimus-eluting stent implantation. The primary and secondary end points were the percentage of uncovered and malapposed struts, respectively, on 6-month follow-up optical coherence tomography. RESULTS: The percentage of uncovered struts was significantly lower in the optical coherence tomography-guided arm (1.60% [1.84]%, [median, 1.06%] vs 4.51% [5.43]% [median, 2.38%]; P = .0004) at 6-month follow-up. The incidence of stents with ≥ 5.9% uncovered struts was also significantly lower in the optical coherence tomography-guided arm (2 patients [3.9%] vs 14 patients [25.9%]; P = .002). In addition, the percentage of malapposed struts was significantly lower in the optical coherence tomography-guided arm (0.19% [0.51]% [median, 0.0%] vs 0.98% [2.53]% [median, 0.0%]; P = .027). CONCLUSIONS: Optical coherence tomography-guided percutaneous coronary intervention significantly reduced the incidence of uncovered stent struts at 6 months compared to angiography-guided percutaneous coronary intervention. These findings suggest that optical coherence tomography-guided percutaneous coronary intervention has a beneficial effect on drug-eluting stent strut coverage.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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