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Nonvascular drug-eluting stent coated with sodium caprate-incorporated polyurethane for the efficient penetration of paclitaxel into tumor tissue

 Dooyong Jeong  ;  Don Haeng Lee  ;  Dong Ki Lee  ;  Kun Na 
 Journal of Biomaterials Applications, Vol.29(8) : 1133-1144, 2015 
Journal Title
 Journal of Biomaterials Applications 
Issue Date
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage* ; Antineoplastic Agents, Phytogenic/pharmacokinetics* ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/pathology ; Biocompatible Materials/chemistry ; Cell Line, Tumor ; Decanoic Acids/chemistry ; Drug-Eluting Stents* ; Humans ; Male ; Materials Testing ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms, Experimental/drug therapy* ; Neoplasms, Experimental/metabolism* ; Neoplasms, Experimental/pathology ; Paclitaxel/administration & dosage* ; Paclitaxel/pharmacokinetics* ; Polyurethanes/chemistry ; Xenograft Model Antitumor Assays
Drug-eluting stent ; cancer therapy ; paclitaxel ; penetration ; sodium caprate
To increase the therapeutic potency of nonvascular drug-eluting stents, sodium caprate was employed as a drug-penetration enhancer. A polytetrafluoroethylene-covered drug-eluting stent was coated with a mixture containing sodium caprate, paclitaxel, and polyurethane via the rolling coating technique. The coated stent has a smooth membrane surface with a 40-µm membrane thickness. Paclitaxel was released from the coated stent for two months. In the multilayered cell sheet model, sodium caprate in the polyurethane membrane (PUSC10) showed the possibility of enhancing the paclitaxel tissue penetration. The amount of penetrated paclitaxel for the sodium caprate-containing polyurethane membrane (PUSC10) was two times higher than that of sodium caprate-free polyurethane membrane. Additionally, the potential of sodium caprate was confirmed by a tumor-bearing small animal model. PUSC10 incorporated with Nile red (as a model fluorescence dye for visualization of drug penetration; PUSC10-Nile red) or PUSC10 incorporated with paclitaxel (PUSC10-paclitaxel) membrane was implanted at tumor sites in Balb/c mice. In the case of PUSC10-Nile red, the tissue penetration depth of Nile red was significantly increased from 30 µm (without sodium caprate) to 1060 µm (with sodium caprate). After seven days, an almost four times higher therapeutic area of PUSC10-paclitaxel was observed compared to that of polyurethane-paclitaxel (without sodium caprate) by a terminal deoxynucleotidyl transferase dUTP nick end labeling assay. The results indicate that sodium caprate improves the penetration and therapeutic efficiencies of drugs in drug-eluting stents, and thus, it has potential for local stent therapy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Dong Ki(이동기) ORCID logo https://orcid.org/0000-0002-0048-9112
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