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Effects of levonorgestrel-releasing intrauterine system on lymphangiogenesis of adenomyosis

Authors
 SiHyun Cho  ;  Young Sik Choi  ;  Bo Hyon Yun  ;  Seung Joo Chon  ;  Yeon Soo Jung  ;  Hye Yeon Kim  ;  Joo Hyun Park  ;  Seok Kyo Seo  ;  Se Hoon Kim  ;  Byung Seok Lee 
Citation
 AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol.143(3) : 352-361, 2015 
Journal Title
 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 
ISSN
 0002-9173 
Issue Date
2015
MeSH
Adenomyosis/drug therapy ; Adenomyosis/pathology* ; Adult ; Female ; Humans ; Hysterectomy ; Immunohistochemistry ; Intrauterine Devices, Medicated/adverse effects* ; Levonorgestrel/administration & dosage* ; Levonorgestrel/therapeutic use ; Lymphangiogenesis/drug effects*
Keywords
Adenomyosis ; D2-40 ; LYVE-1 ; Levonorgestrel-releasing intrauterine system ; Lymphangiogenesis
Abstract
OBJECTIVES: Lymphangiogenesis may be involved in the pathogenesis of adenomyosis. We investigated the lymphatic vessels of patients with adenomyosis, including those treated with levonorgestrel-releasing intrauterine system (LNG-IUS). METHODS: Full-thickness uterine samples were obtained from patients who received hysterectomies. Twenty-one patients with adenomyosis and 17 patients with adenomyosis who were treated with LNG-IUS were included. Eighteen patients with cervical intraepithelial neoplasia served as controls. Immunohistochemical staining was performed with antibodies against podoplanin and lymphatic vessel endothelial hyaluronan receptor 1. The lymphovascular density (LVD) was analyzed in each sample by the "hot spot" method. RESULTS: The LVDs were significantly higher in the endometrial and myometrial tissues of patients with adenomyosis compared with those of patients treated with the LNG-IUS or controls. No significant differences were noted between the LNG-IUS-treated group and controls. Evaluation of the LVDs according to the menstrual cycle showed that the differences in the endometrial tissues of the adenomyosis group and those of the LNG-IUS-treated group or the controls were more prominent during the secretory phase. CONCLUSIONS: Treatment with the LNG-IUS resulted in reduced lymphangiogenesis and LVD in the endometrial and myometrial tissues of patients with adenomyosis. Reduced lymphangiogenesis may be one mechanism by which the LNG-IUS reduces adenomyosis-related symptoms.
Full Text
http://ajcp.ascpjournals.org/content/143/3/352.long
DOI
10.1309/AJCPP8F4SFYFVXRN
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Hye Yeon(김혜연)
Park, Joo Hyun(박주현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Chon, Seung Joo(전승주)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139506
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