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The neuromodulation of neuropathic pain by measuring pain response rate and pain response duration in animal

DC Field Value Language
dc.contributor.author김진형-
dc.contributor.author신재우-
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.date.accessioned2016-02-04T10:59:32Z-
dc.date.available2016-02-04T10:59:32Z-
dc.date.issued2015-
dc.identifier.issn2005-3711-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139427-
dc.description.abstractOBJECTIVE: Neuropathic pain causes patients feel indescribable pain. Deep Brain Stimulation (DBS) is one of the treatment methods in neuropathic pain but the action mechanism is still unclear. To study the effect and mechanism of analgesic effects from DBS in neuropathic pain and to enhance the analgesic effect of DBS, we stimulated the ventral posterolateral nucleus (VPL) in rats. METHODS: To observe the effect from VPL stimulation, we established 3 groups : normal group (Normal group), neuropathic pain group (Pain group) and neuropathic pain+DBS group (DBS group). Rats in DBS group subjected to electrical stimulation and the target is VPL. RESULTS: We observed the behavioral changes by DBS in VPL (VPL-DBS) on neuropathic pain rats. In our study, the pain score which is by conventional test method was effectively decreased. In specific, the time of showing withdrawal response from painful stimulation which is not used measuring method in our animal model was also decreased by DBS. CONCLUSION: The VPL is an effective target on pain modulation. Specifically we could demonstrate changes of pain response duration which is not used, and it was also significantly meaningful. We thought that this study would be helpful in understanding the relation between VPL-DBS and neuropathic pain.-
dc.description.statementOfResponsibilityopen-
dc.format.extent6~11-
dc.relation.isPartOfJOURNAL OF KOREAN NEUROSURGICAL SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe neuromodulation of neuropathic pain by measuring pain response rate and pain response duration in animal-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJinhyung Kim-
dc.contributor.googleauthorSung Eun Lee-
dc.contributor.googleauthorJaewoo Shin-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorSung June Kim-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.3340/jkns.2015.57.1.6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02141-
dc.contributor.localIdA03484-
dc.contributor.localIdA03775-
dc.contributor.localIdA01031-
dc.relation.journalcodeJ01520-
dc.identifier.eissn1598-7876-
dc.identifier.pmid25674337-
dc.subject.keywordDeep brain stimulation-
dc.subject.keywordNeuromodulation-
dc.subject.keywordNeuropathic pain-
dc.subject.keywordVentral poterolateral nucleus-
dc.contributor.alternativeNameKim, Jin Hyung-
dc.contributor.alternativeNameShin, Jae Woo-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.alternativeNameJung, Hyun Ho-
dc.contributor.affiliatedAuthorShin, Jae Woo-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.contributor.affiliatedAuthorJung, Hyun Ho-
dc.contributor.affiliatedAuthorKim, Jin Hyung-
dc.rights.accessRightsfree-
dc.citation.volume57-
dc.citation.number1-
dc.citation.startPage6-
dc.citation.endPage11-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN NEUROSURGICAL SOCIETY, Vol.57(1) : 6-11, 2015-
dc.identifier.rimsid55388-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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