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Effect of mild hypocapnia on hemodynamic and bispectral index responses to tracheal intubation during propofol anesthesia in children

Authors
 Hyun Jeong Kwak  ;  Ji Young Kim  ;  Kyung Cheon Lee  ;  Hong Soon Kim  ;  Jong Yeop Kim 
Citation
 JOURNAL OF CLINICAL MONITORING AND COMPUTING, Vol.29(1) : 29-33, 2015 
Journal Title
JOURNAL OF CLINICAL MONITORING AND COMPUTING
ISSN
 1387-1307 
Issue Date
2015
MeSH
Alfentanil/chemistry ; Anesthesia, General/methods* ; Blood Pressure ; Carbon Dioxide/chemistry ; Child ; Female ; Heart Rate ; Hemodynamics ; Humans ; Hypocapnia/diagnosis* ; Intubation ; Intubation, Intratracheal/methods ; Male ; Propofol/therapeutic use* ; Random Allocation ; Reproducibility of Results ; Systole ; Time Factors ; Trachea/pathology*
Keywords
Bispectral index ; Hypocapnia ; Tracheal intubation
Abstract
The purpose of this study was to investigate the effect of mild hypocapnia on hypertension and arousal response after tracheal intubation in children during propofol anesthesia. Forty-four children, American Society of Anesthesiologists physical status I-II patients, aged 3-9 years were randomly allocated to either the normocapnia group [end-tidal carbon dioxide tension (ETCO2=35 mmHg, n=22)] or the hypocapnia group (ETCO2=25 mmHg, n=22). Anesthesia was induced with propofol 2.5 mg/kg. Five minutes after the administration of rocuronium 0.6 mg/kg, laryngoscopy was attempted. The mean arterial pressure (MAP), heart rate (HR), SpO2 and bispectral index (BIS) were measured during induction and intubation periods. The maximal change in the BIS with tracheal intubation (ΔBIS) was defined as the difference between the baseline value and the maximal value within the first 5 min after intubation. Before tracheal intubation, the change in BIS over time was not different between the groups. After tracheal intubation, the changes in the MAP, HR and BIS over time were not significantly different between the groups. The mean value±SD of ΔBIS was 5.7±5.2 and 7.4±5.5 in the normocapnia and hypocapnia groups, respectively, without any intergroup difference. This study showed that mild hypocapnia did not attenuate hemodynamic and BIS responses to tracheal intubation in children during propofol anesthesia. Our results suggested that hyperventilation has no beneficial effect on hemodynamic and arousal responses to tracheal intubation in children.
Full Text
http://link.springer.com/article/10.1007%2Fs10877-014-9564-8
DOI
10.1007/s10877-014-9564-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Young(김지영) ORCID logo https://orcid.org/0000-0001-5822-0338
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139381
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