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Factors associated with significant liver fibrosis assessed using transient elastography in general population

 Seng Chan You  ;  Kwang Joon Kim  ;  Seung Up Kim  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Won Jae Lee  ;  Kwang-Hyub Han 
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.21(4) : 1158-1166, 2015 
Journal Title
Issue Date
Aged ; Carotid Artery Diseases/diagnosis ; Carotid Artery Diseases/epidemiology ; Case-Control Studies ; Chi-Square Distribution ; Comorbidity ; Elasticity Imaging Techniques* ; Female ; Humans ; Liver/diagnostic imaging* ; Liver Cirrhosis/diagnostic imaging* ; Liver Cirrhosis/epidemiology ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Factors ; Severity of Illness Index ; Vascular Calcification/diagnosis ; Vascular Calcification/epidemiology
Alanine aminotransferase ; Body mass index ; Carotid artery plaque ; Carotid intimal medial thickness ; Fibroscan ; Healthy subjects ; Liver fibrosis ; Non-alcoholic fatty liver disease ; Non-alcoholic steatohepatitis ; Transient elastography
AIM: To investigate the prevalence of significant liver fibrosis assessed using transient elastography (TE) and its predictors in asymptomatic general population.
METHODS: A total of 159 subjects without chronic viral hepatitis who underwent comprehensive medical health check-up between January 2012 and July 2012 were prospectively recruited. Significant liver fibrosis was defined as liver stiffness value>7.0 kPa.
RESULTS: The mean age and body mass index (BMI) of the study population (men 54.7%) was 56.0 years and 24.3 kg/m2. Among the study subjects, 11 (6.9%) showed significant liver fibrosis. On univariate analysis, BMI, alanine aminotransferase (ALT), homeostasis model assessment of insulin resistance, carotid intimal media thickness (IMT), number of calcified plaques on carotid ultrasound, and visceral fat area on computed tomography were significantly higher in subjects with significant liver fibrosis than in those without (all P<0.05). However, on multivariate analysis, BMI [odds ratio (OR)=.487; P=0.045], ALT (OR=1.078; P=0.014), carotid IMT (OR=3.244; P=0.027), and the number of calcified carotid plaques (OR=1.787; P=0.031) were independent predictors of significant liver fibrosis.
CONCLUSION: The prevalence of significant liver fibrosis assessed using TE was 6.9% in apparently healthy subjects. High BMI, high ALT, thicker carotid IMT, and higher numbers of calcified carotid plaques were independently associated with the presence of significant liver fibrosis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
You, Seng Chan(유승찬) ORCID logo https://orcid.org/0000-0002-5052-6399
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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