Cited 21 times in
Pre-clinical evaluation of the osteogenic potential of bone morphogenetic protein-2 loaded onto a particulate porcine bone biomaterial
DC Field | Value | Language |
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dc.contributor.author | 김민수 | - |
dc.contributor.author | 이중석 | - |
dc.contributor.author | 임현창 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2016-02-04T10:56:26Z | - |
dc.date.available | 2016-02-04T10:56:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139315 | - |
dc.description.abstract | AIM: The objective of study was to determine the osteogenic potential of bone morphogenetic protein-2 (BMP-2) loaded onto a particulate porcine bone mineral (PBM) biomaterial using a sinus augmentation model. METHODS: Release kinetics of BMP-2/PBM was determined in vitro. Eight rabbits received BMP-2/PBM or PBM alone into contra-lateral sinus sites. The animals were killed following a 2-week healing interval for micro-CT and histometrical analysis. RESULTS: Approximately 40% of the BMP-2 was released from PBM over the first 3 days in vitro; release maintained at a reduced level through day 21. In vivo, total augmented implant volume did not differ significantly between treatments. However, local bone formation was enhanced in the BMP-2/PBM group compared with PBM control (10.5% versus 6.6%; p = 0.03), specifically in the central aspect of the PBM implant (14.2% versus 5.5%; p < 0.01) and adjoining the Schneiderian membrane (11.9% versus 5.0%; p < 0.05). There were no significant overall differences in residual biomaterial and fibrovascular tissue. CONCLUSION: Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 81~88 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biocompatible Materials/therapeutic use* | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/pharmacokinetics | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/therapeutic use* | - |
dc.subject.MESH | Bone Substitutes/therapeutic use* | - |
dc.subject.MESH | Drug Evaluation, Preclinical | - |
dc.subject.MESH | Giant Cells/pathology | - |
dc.subject.MESH | Image Processing, Computer-Assisted/methods | - |
dc.subject.MESH | Imaging, Three-Dimensional/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maxillary Sinus/drug effects | - |
dc.subject.MESH | Maxillary Sinus/pathology | - |
dc.subject.MESH | Nasal Mucosa/drug effects | - |
dc.subject.MESH | Nasal Mucosa/pathology | - |
dc.subject.MESH | Osteogenesis/drug effects* | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Sinus Floor Augmentation/methods* | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | X-Ray Microtomography/methods | - |
dc.title | Pre-clinical evaluation of the osteogenic potential of bone morphogenetic protein-2 loaded onto a particulate porcine bone biomaterial | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jeyoung Yon | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Hyun-Chang Lim | - |
dc.contributor.googleauthor | Min-Soo Kim | - |
dc.contributor.googleauthor | Ji-Youn Hong | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.identifier.doi | 10.1111/jcpe.12329 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03417 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A00462 | - |
dc.contributor.localId | A03185 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J01337 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.pmid | 25370371 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12329/abstract | - |
dc.subject.keyword | Schneiderian membrane | - |
dc.subject.keyword | animal model | - |
dc.subject.keyword | bone morphogenetic protein-2 | - |
dc.subject.keyword | bone regeneration | - |
dc.subject.keyword | xenograft | - |
dc.contributor.alternativeName | Kim, Min Soo | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Lim, Hyun Chang | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Lim, Hyun Chang | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Kim, Min Soo | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 88 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.42(1) : 81-88, 2015 | - |
dc.identifier.rimsid | 45563 | - |
dc.type.rims | ART | - |
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