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Treatment outcomes of extended-field radiation therapy and the effect of concurrent chemotherapy on uterine cervical cancer with para-aortic lymph node metastasis

DC Field Value Language
dc.contributor.author금기창-
dc.contributor.author김귀언-
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김용배-
dc.contributor.author남은지-
dc.contributor.author윤홍인-
dc.contributor.author차지혜-
dc.date.accessioned2016-02-04T10:55:36Z-
dc.date.available2016-02-04T10:55:36Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139284-
dc.description.abstractPURPOSE: To review the clinical outcomes of extended-field radiation therapy (EFRT) and to analyze prognostic factors significant for survival in patients receiving EFRT for uterine cervical carcinoma with para-aortic node (PAN) metastasis. PATIENTS AND METHODS: We retrospectively reviewed 90 patients with stage IB-IVA cervical cancer and PAN metastasis between 1987 and 2012. Median age was 50 (range, 24-77). Patients received median 70.2 Gy (range, 56-93) to point A and median 50.4 Gy (range, 45-60.4) to PAN over median 69 elapsed days (range, 43-182). Forty-six patients (51.1%) received concurrent chemotherapy. Survival was calculated using the Kaplan-Meier method. We analyzed prognostic factors for overall actuarial survival (OS) and progression-free survival (PFS) using a Cox regression method. RESULTS: The median follow-up period for surviving patients was 55 months (range, 3-252). Seventy patients (77.8%) had complete remission. Forty-six patients experienced treatment failure as follows: 11 patients (12.2%) as local recurrence, 19 (21%) as regional recurrence and 33 (36.7%) as distant metastasis. The 5-yr OS and PFS were 62.6% and 43.9%, respectively. Treatment response was the only statistically independent prognostic factors for OS (p= 0.04) and PFS (p< 0.001) on multivariate analysis. Grade 3 or 4 hematologic gastrointestinal and urogenital toxicities were observed in about 10% of patients. CONCLUSIONS: Our institutional experiences showed that EFRT was an effective treatment for cervical cancer patients with PAN metastasis. The addition of chemotherapy to EFRT seems to have uncertain survival benefit with higher hematologic toxicity.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfRADIATION ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use*-
dc.subject.MESHCarboplatin/administration & dosage-
dc.subject.MESHCarcinoma, Large Cell/mortality-
dc.subject.MESHCarcinoma, Large Cell/secondary-
dc.subject.MESHCarcinoma, Large Cell/therapy*-
dc.subject.MESHCarcinoma, Squamous Cell/mortality-
dc.subject.MESHCarcinoma, Squamous Cell/secondary-
dc.subject.MESHCarcinoma, Squamous Cell/therapy*-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHCisplatin/administration & dosage-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPara-Aortic Bodies/drug effects-
dc.subject.MESHPara-Aortic Bodies/pathology*-
dc.subject.MESHPara-Aortic Bodies/radiation effects-
dc.subject.MESHPrognosis-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHUterine Cervical Neoplasms/mortality-
dc.subject.MESHUterine Cervical Neoplasms/pathology-
dc.subject.MESHUterine Cervical Neoplasms/therapy*-
dc.subject.MESHYoung Adult-
dc.titleTreatment outcomes of extended-field radiation therapy and the effect of concurrent chemotherapy on uterine cervical cancer with para-aortic lymph node metastasis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorHa Yoon Lee-
dc.contributor.googleauthorEun Ji Nam-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.contributor.googleauthorGwi Eon Kim-
dc.contributor.googleauthorYong Bae Kim-
dc.identifier.doi10.1186/s13014-014-0320-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00744-
dc.contributor.localIdA00595-
dc.contributor.localIdA00272-
dc.contributor.localIdA00321-
dc.contributor.localIdA00526-
dc.contributor.localIdA00729-
dc.contributor.localIdA01262-
dc.contributor.localIdA04009-
dc.contributor.localIdA04777-
dc.relation.journalcodeJ02591-
dc.identifier.eissn1748-717X-
dc.identifier.pmid25582425-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKim, Gwi Eon-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNameYoon, Hong In-
dc.contributor.alternativeNameCha, Ji Hye-
dc.contributor.affiliatedAuthorKim, Yong Bae-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKim, Gwi Eon-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorCha, Ji Hye-
dc.contributor.affiliatedAuthorYoon, Hong In-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.startPage18-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY, Vol.10 : 18, 2015-
dc.identifier.rimsid45543-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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