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Altered cingulo-striatal function underlies reward drive deficits in schizophrenia

Authors
 Il Ho Park  ;  Ji Won Chun  ;  Hae-Jeong Park  ;  Min-Seong Koo  ;  Sunyoung Park  ;  Seok-Hyeong Kim  ;  Jae-Jin Kim 
Citation
 SCHIZOPHRENIA RESEARCH, Vol.161(2~3) : 229-236, 2015 
Journal Title
 SCHIZOPHRENIA RESEARCH 
ISSN
 0920-9964 
Issue Date
2015
MeSH
Adult ; Analysis of Variance ; Corpus Striatum/blood supply ; Corpus Striatum/pathology* ; Female ; Games, Experimental ; Gyrus Cinguli/blood supply ; Gyrus Cinguli/pathology* ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Motivation/physiology* ; Oxygen/blood ; Reinforcement (Psychology) ; Schizophrenia/pathology* ; Schizophrenia/physiopathology* ; Schizophrenic Psychology* ; Statistics as Topic ; Young Adult
Keywords
Amotivation ; Anterior cingulate cortex ; Incentive motivation ; Schizophrenia ; Striatum
Abstract
Amotivation in schizophrenia is assumed to involve dysfunctional dopaminergic signaling of reward prediction or anticipation. It is unclear, however, whether the translation of neural representation of reward value to behavioral drive is affected in schizophrenia. In order to examine how abnormal neural processing of response valuation and initiation affects incentive motivation in schizophrenia, we conducted functional MRI using a deterministic reinforcement learning task with variable intervals of contingency reversals in 20 clinically stable patients with schizophrenia and 20 healthy controls. Behaviorally, the advantage of positive over negative reinforcer in reinforcement-related responsiveness was not observed in patients. Patients showed altered response valuation and initiation-related striatal activity and deficient rostro-ventral anterior cingulate cortex activation during reward approach initiation. Among these neural abnormalities, rostro-ventral anterior cingulate cortex activation was correlated with positive reinforcement-related responsiveness in controls and social anhedonia and social amotivation subdomain scores in patients. Our findings indicate that the central role of the anterior cingulate cortex is in translating action value into driving force of action, and underscore the role of the cingulo-striatal network in amotivation in schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0920996414006434
DOI
10.1016/j.schres.2014.11.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Sunyoung(박선영)
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139277
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