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Identification of a subnuclear body involved in sequence-specific cytokine RNA processing

DC Field Value Language
dc.contributor.author김승원-
dc.contributor.author천재희-
dc.date.accessioned2016-02-04T10:54:22Z-
dc.date.available2016-02-04T10:54:22Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139238-
dc.description.abstractProcessing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts as an InSAC scaffold that selectively associates with IL-6 and IL-10 RNAs in a sequence-specific manner. TDP-43 also recruits key spliceosomal components from Cajal bodies. LPS induces posttranslational modifications of TDP-43; in particular, TDP-43 ubiquitination provides a driving force for InSAC formation. As a consequence, in vivo depletion of TDP-43 leads to a dramatic reduction in the RNA processing and the protein levels of IL-6 in serum. Collectively, our findings highlight the importance of TDP-43-mediated InSAC biogenesis in immune regulation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDNA-Binding Proteins/metabolism*-
dc.subject.MESHElectrophoretic Mobility Shift Assay-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHHumans-
dc.subject.MESHImmunity, Cellular/genetics*-
dc.subject.MESHImmunoblotting-
dc.subject.MESHImmunoprecipitation-
dc.subject.MESHIn Situ Hybridization, Fluorescence-
dc.subject.MESHInterleukin-10/metabolism-
dc.subject.MESHInterleukin-6/metabolism-
dc.subject.MESHIntranuclear Space/physiology*-
dc.subject.MESHLipopolysaccharides-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHRNA Interference-
dc.subject.MESHRNA Processing, Post-Transcriptional/physiology*-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHSpliceosomes/metabolism*-
dc.subject.MESHUbiquitination-
dc.titleIdentification of a subnuclear body involved in sequence-specific cytokine RNA processing-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorSungwook Lee-
dc.contributor.googleauthorTaeyun A. Lee-
dc.contributor.googleauthorEunhye Lee-
dc.contributor.googleauthorSujin Kang-
dc.contributor.googleauthorAreum Park-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorHyo Jin Park-
dc.contributor.googleauthorJe-Hyun Yoon-
dc.contributor.googleauthorSang-Jun Ha-
dc.contributor.googleauthorTaesun Park-
dc.contributor.googleauthorJu-Seog Lee-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorBoyoun Park-
dc.identifier.doi10.1038/ncomms6791-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00656-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid25557830-
dc.identifier.urlhttp://www.nature.com/ncomms/2015/150105/ncomms6791/full/ncomms6791.html-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.rights.accessRightsnot free-
dc.citation.volume6-
dc.citation.startPage5791-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.6 : 5791, 2015-
dc.identifier.rimsid45514-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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