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Neuroprotective effect of 3-morpholinosydnonimine against Zn2+-induced PC12 cell death

DC FieldValueLanguage
dc.contributor.author강정완-
dc.contributor.author문성아-
dc.contributor.author서정택-
dc.contributor.author안정미-
dc.contributor.author홍수영-
dc.date.accessioned2016-02-04T10:54:16Z-
dc.date.available2016-02-04T10:54:16Z-
dc.date.issued2015-
dc.identifier.issn0014-2999-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139234-
dc.description.abstractExcessive intracellular accumulation of zinc (Zn2+) is neurotoxic and contributes to a number of neuropathological conditions. Here, we investigated the protective effect of 3-morpholinosydnonimine (SIN-1) against Zn2+-induced neuronal cell death in differentiated PC12 cells. We found that Zn2+-induced PC12 cell death was reduced in a concentration-dependent manner by pretreatment with SIN-1. The intracellular accumulation of Zn2+ was not affected by pretreatment with SIN-1, indicating that SIN-1-induced neuroprotection was not attributable to reduced influx of Zn2+ into cells. SIN-1C, the stable decomposition product of SIN-1, failed to prevent Zn2+-induced cell death. Furthermore, the protective effect of SIN-1 against Zn2+-induced PC12 cell death was almost completely abolished by uric acid, a free radical scavenger, suggesting that reactive oxygen and nitrogen species generated by SIN-1 may contribute to the protective effect. SIN-1 prevented the inactivation of glutathione reductase (GR) and the increase in the ratio of oxidized glutathione/total glutathione (GSSG/total GSH) induced by Zn2+. Addition of membrane permeable GSH ethyl ester (GSH-EE) to PC12 cells prior to Zn2+ treatment significantly increased cell viability. We therefore conclude that SIN-1 may exert neuroprotective effect against Zn2+-induced cell death in differentiated PC12 cells by preventing inhibition of GR and increase in GSSG/total GSH ratio.-
dc.description.statementOfResponsibilityopen-
dc.format.extent37~44-
dc.relation.isPartOfEUROPEAN JOURNAL OF PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Death/drug effects-
dc.subject.MESHEnzyme Activation/drug effects-
dc.subject.MESHGlutathione Disulfide/metabolism-
dc.subject.MESHGlutathione Reductase/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMolsidomine/analogs & derivatives*-
dc.subject.MESHMolsidomine/pharmacology-
dc.subject.MESHNeurons/cytology-
dc.subject.MESHNeurons/drug effects-
dc.subject.MESHNeurons/metabolism-
dc.subject.MESHNeuroprotective Agents/pharmacology*-
dc.subject.MESHPC12 Cells-
dc.subject.MESHRats-
dc.subject.MESHZinc/adverse effects*-
dc.subject.MESHZinc/metabolism-
dc.titleNeuroprotective effect of 3-morpholinosydnonimine against Zn2+-induced PC12 cell death-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral and Maxillofacial Surgery (구강악안면외과학)-
dc.contributor.googleauthorJeong Mi An-
dc.contributor.googleauthorSeong Ah Moon-
dc.contributor.googleauthorSoo Young Hong-
dc.contributor.googleauthorJeong Wan Kang-
dc.contributor.googleauthorJeong Taeg Seo-
dc.identifier.doi10.1016/j.ejphar.2014.12.003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00078-
dc.contributor.localIdA01362-
dc.contributor.localIdA01905-
dc.contributor.localIdA02257-
dc.contributor.localIdA04409-
dc.relation.journalcodeJ00842-
dc.identifier.eissn1879-0712-
dc.identifier.pmid25523480-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0014299914008619-
dc.subject.keywordGlutathione reductase-
dc.subject.keywordNeuroprotection-
dc.subject.keywordPC12 cells-
dc.subject.keywordSIN-1-
dc.subject.keywordZn(2+)-
dc.contributor.alternativeNameKang, Jeong Wan-
dc.contributor.alternativeNameMoon, Seong Ah-
dc.contributor.alternativeNameSeo, Jeong Taeg-
dc.contributor.alternativeNameAn, Jeong Mi-
dc.contributor.alternativeNameHong, Soo Young-
dc.contributor.affiliatedAuthorKang, Jeong Wan-
dc.contributor.affiliatedAuthorMoon, Seong Ah-
dc.contributor.affiliatedAuthorSeo, Jeong Taeg-
dc.contributor.affiliatedAuthorAn, Jeong Mi-
dc.contributor.affiliatedAuthorHong, Soo Young-
dc.rights.accessRightsnot free-
dc.citation.volume748-
dc.citation.startPage37-
dc.citation.endPage44-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF PHARMACOLOGY, Vol.748 : 37-44, 2015-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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