Cited 3 times in
Neuroprotective effect of 3-morpholinosydnonimine against Zn2+-induced PC12 cell death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강정완 | - |
dc.contributor.author | 문성아 | - |
dc.contributor.author | 서정택 | - |
dc.contributor.author | 안정미 | - |
dc.contributor.author | 홍수영 | - |
dc.date.accessioned | 2016-02-04T10:54:16Z | - |
dc.date.available | 2016-02-04T10:54:16Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139234 | - |
dc.description.abstract | Excessive intracellular accumulation of zinc (Zn2+) is neurotoxic and contributes to a number of neuropathological conditions. Here, we investigated the protective effect of 3-morpholinosydnonimine (SIN-1) against Zn2+-induced neuronal cell death in differentiated PC12 cells. We found that Zn2+-induced PC12 cell death was reduced in a concentration-dependent manner by pretreatment with SIN-1. The intracellular accumulation of Zn2+ was not affected by pretreatment with SIN-1, indicating that SIN-1-induced neuroprotection was not attributable to reduced influx of Zn2+ into cells. SIN-1C, the stable decomposition product of SIN-1, failed to prevent Zn2+-induced cell death. Furthermore, the protective effect of SIN-1 against Zn2+-induced PC12 cell death was almost completely abolished by uric acid, a free radical scavenger, suggesting that reactive oxygen and nitrogen species generated by SIN-1 may contribute to the protective effect. SIN-1 prevented the inactivation of glutathione reductase (GR) and the increase in the ratio of oxidized glutathione/total glutathione (GSSG/total GSH) induced by Zn2+. Addition of membrane permeable GSH ethyl ester (GSH-EE) to PC12 cells prior to Zn2+ treatment significantly increased cell viability. We therefore conclude that SIN-1 may exert neuroprotective effect against Zn2+-induced cell death in differentiated PC12 cells by preventing inhibition of GR and increase in GSSG/total GSH ratio. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 37~44 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Glutathione Disulfide/metabolism | - |
dc.subject.MESH | Glutathione Reductase/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Molsidomine/analogs & derivatives* | - |
dc.subject.MESH | Molsidomine/pharmacology | - |
dc.subject.MESH | Neurons/cytology | - |
dc.subject.MESH | Neurons/drug effects | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Neuroprotective Agents/pharmacology* | - |
dc.subject.MESH | PC12 Cells | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Zinc/adverse effects* | - |
dc.subject.MESH | Zinc/metabolism | - |
dc.title | Neuroprotective effect of 3-morpholinosydnonimine against Zn2+-induced PC12 cell death | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery (구강악안면외과학) | - |
dc.contributor.googleauthor | Jeong Mi An | - |
dc.contributor.googleauthor | Seong Ah Moon | - |
dc.contributor.googleauthor | Soo Young Hong | - |
dc.contributor.googleauthor | Jeong Wan Kang | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.identifier.doi | 10.1016/j.ejphar.2014.12.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00078 | - |
dc.contributor.localId | A01362 | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A02257 | - |
dc.contributor.localId | A04409 | - |
dc.relation.journalcode | J00842 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.identifier.pmid | 25523480 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0014299914008619 | - |
dc.subject.keyword | Glutathione reductase | - |
dc.subject.keyword | Neuroprotection | - |
dc.subject.keyword | PC12 cells | - |
dc.subject.keyword | SIN-1 | - |
dc.subject.keyword | Zn(2+) | - |
dc.contributor.alternativeName | Kang, Jeong Wan | - |
dc.contributor.alternativeName | Moon, Seong Ah | - |
dc.contributor.alternativeName | Seo, Jeong Taeg | - |
dc.contributor.alternativeName | An, Jeong Mi | - |
dc.contributor.alternativeName | Hong, Soo Young | - |
dc.contributor.affiliatedAuthor | Kang, Jeong Wan | - |
dc.contributor.affiliatedAuthor | Moon, Seong Ah | - |
dc.contributor.affiliatedAuthor | Seo, Jeong Taeg | - |
dc.contributor.affiliatedAuthor | An, Jeong Mi | - |
dc.contributor.affiliatedAuthor | Hong, Soo Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 748 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 44 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.748 : 37-44, 2015 | - |
dc.identifier.rimsid | 45511 | - |
dc.type.rims | ART | - |
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