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Association between body mass index and cortical thickness: among elderly cognitively normal men and women

 Hojeong Kim  ;  Changsoo Kim  ;  Sang Won Seo  ;  Duk L. Na  ;  Hee Jin Kim  ;  Mira Kang  ;  Hee-Young Shin  ;  Seong Kyung Cho  ;  Sang eon Park  ;  Jeongmin Lee  ;  Jung Won Hwang  ;  Seun Jeon  ;  Jong-Min Lee  ;  Geon Ha Kim  ;  Hanna Cho  ;  Byoung Seok Ye  ;  Young Noh  ;  Cindy W. Yoon  ;  Eliseo Guallar 
Journal Title
Issue Date
Aged ; Atrophy ; Brain/pathology* ; Brain Mapping/methods ; Dementia*/diagnosis ; Dementia*/epidemiology ; Dementia*/physiopathology ; Female ; Humans ; Intelligence Tests ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Obesity*/diagnosis ; Obesity*/epidemiology ; Obesity*/psychology ; Regression Analysis ; Republic of Korea ; Risk Factors ; Sex Factors
cortical thickness ; BMI ; underweight ; overweight ; dementia
BACKGROUND: There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants. METHODS: We recruited cognitively normal participants (n = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders. RESULTS: Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant. CONCLUSIONS: Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
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