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Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women

Authors
 Seok Kyo Seo  ;  Bo Hyon Yun  ;  Seung Joo Chon  ;  Yoo Jin Lee  ;  E-jung Han  ;  Joo Hyun Park  ;  SiHyun Cho  ;  Young Sik Choi  ;  Byung Seok Lee 
Citation
 CLINICA CHIMICA ACTA, Vol.438 : 62-66, 2015 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2015
MeSH
Coronary Artery Disease/blood* ; Female ; Ferritins/blood* ; Humans ; Metabolic Syndrome/blood* ; Middle Aged ; Postmenopause* ; Republic of Korea
Keywords
Coronary atherosclerosis ; Ferritin ; Menopause ; Metabolic syndrome
Abstract
BACKGROUND: Several studies have suggested that increased iron storage may promote the development of atherosclerotic coronary heart disease. In the present study, we aimed to investigate the association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women. METHODS: We examined 280 postmenopausal women who visited the health promotion center of our hospital for a routine health checkup. Metabolic syndrome was diagnosed by using the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III. The presence of coronary atherosclerosis was indicated by 64-row multi-detector computed tomography. RESULTS: The proportion of postmenopausal women with metabolic syndrome and coronary atherosclerosis in the highest ferritin quartile was significantly higher compared with that in the lowest quartile. Serum ferritin levels were independently associated with the presence of metabolic syndrome (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.313; 95% confidence interval, 1.251-8.775) and coronary atherosclerosis (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.047; 95% confidence interval, 1.026-9.051), after adjusting for confounding factors. CONCLUSIONS: Elevated serum ferritin levels may be associated with an increased risk of metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898114003386
DOI
10.1016/j.cca.2014.07.042
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Joo Hyun(박주현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Lee, Yoo Jin(이유진)
Chon, Seung Joo(전승주)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
Han, E Jung(한이정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139197
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