Cited 26 times in
Comparison of collagen membrane and bone substitute as a carrier for rhBMP-2 in lateral onlay graft
DC Field | Value | Language |
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dc.contributor.author | 김민수 | - |
dc.contributor.author | 이중석 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 채중규 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2016-02-04T10:52:59Z | - |
dc.date.available | 2016-02-04T10:52:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0905-7161 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139188 | - |
dc.description.abstract | OBJECTIVES: To evaluate the bone regenerative effect of bioresorbable collagen membrane (CM) as a carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) when performing lateral onlay grafts using bovine hydroxyapatite incorporated with collagen matrix (BHC) in combination with CM in dogs. MATERIAL AND METHODS: A guided bone regeneration (GBR) was performed at the buccal aspect of edentulous maxillary alveolar ridges in dogs (n = 5): (1) BHC group, in which rhBMP-2-loaded BHC was covered by a CM, and (2) CM group, in which BHC was covered by an rhBMP-2-loaded CM. A histologic and histometric analysis was performed after 8 weeks of healing. RESULTS: Both the BHC and CM groups exhibited substantial newly formed bone (NB). More NB was found in the CM group than in the BHC group without statistical significance. Most of the NB was in direct contact with the residual bone substitute in the BHC group, whereas the projections and islands of NB were observed in the spaces between the residual bone substitute clusters in the CM group. The bone-to-residual bone substitute contact ratio was significantly lower in the CM group than in the BHC group (P = 0.043). CONCLUSIONS: Within the limitations of this study, it can be concluded that rhBMP-2-loaded CM performed lateral onlay grafts as effectively as rhBMP-2-loaded BHC while showing less bone-residual bone substitute contact ratio in dogs. The loading of CMs with rhBMP-2 might therefore be a recommendable treatment option for facilitating lateral onlay graft combined with rhBMP-2. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e13~e19 | - |
dc.relation.isPartOf | CLINICAL ORAL IMPLANTS RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorbable Implants | - |
dc.subject.MESH | Alveolar Process/surgery* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/administration & dosage | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/pharmacology* | - |
dc.subject.MESH | Bone Regeneration/drug effects* | - |
dc.subject.MESH | Bone Substitutes/pharmacology* | - |
dc.subject.MESH | Collagen/pharmacology* | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Guided Tissue Regeneration, Periodontal/methods* | - |
dc.subject.MESH | Maxilla/surgery | - |
dc.subject.MESH | Membranes, Artificial* | - |
dc.subject.MESH | Recombinant Proteins/administration & dosage | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Transforming Growth Factor beta/administration & dosage | - |
dc.subject.MESH | Transforming Growth Factor beta/pharmacology* | - |
dc.subject.MESH | Wound Healing/physiology | - |
dc.title | Comparison of collagen membrane and bone substitute as a carrier for rhBMP-2 in lateral onlay graft | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Yun-Young Chang | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Min-Soo Kim | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Jung-Kiu Chai | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.identifier.doi | 10.1111/clr.12320 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A04024 | - |
dc.contributor.localId | A00462 | - |
dc.contributor.localId | A03185 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J00600 | - |
dc.identifier.eissn | 1600-0501 | - |
dc.identifier.pmid | 24350566 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/clr.12320/abstract | - |
dc.subject.keyword | Bio-OSS | - |
dc.subject.keyword | bone morphogenetic protein 2 | - |
dc.subject.keyword | bone regeneration | - |
dc.subject.keyword | collagen | - |
dc.subject.keyword | histology | - |
dc.contributor.alternativeName | Kim, Min Soo | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Chai, Jung Kyu | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Chai, Jung Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Min Soo | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 19 | - |
dc.identifier.bibliographicCitation | CLINICAL ORAL IMPLANTS RESEARCH, Vol.26(1) : 13-19, 2015 | - |
dc.identifier.rimsid | 43820 | - |
dc.type.rims | ART | - |
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