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Effect of recombinant human epidermal growth factor on cutaneous scar quality in thyroidectomy patients

Authors
 Jung U Shin  ;  Sang-Wook Kang  ;  Jong Ju Jeong  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Ju Hee Lee 
Citation
 JOURNAL OF DERMATOLOGICAL TREATMENT, Vol.26(2) : 159-164, 2015 
Journal Title
 JOURNAL OF DERMATOLOGICAL TREATMENT 
ISSN
 0954-6634 
Issue Date
2015
MeSH
Adult ; Cicatrix/drug therapy* ; Epidermal Growth Factor/therapeutic use* ; Erythema/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Recombinant Proteins ; Thyroidectomy/adverse effects ; Thyroidectomy/methods* ; Wound Healing/drug effects*
Keywords
Epidermal growth factor ; prevention ; scars
Abstract
BACKGROUND: Epidermal growth factor (EGF) decreases inflammatory cell infiltration and TGF-β expression during wound healing. Several clinical studies show that recovery of various ulcer wounds, such as diabetic and radiation ulcer, is promoted by EGF. OBJECTIVE: To evaluate effects of recombinant human epidermal growth factor (rhEGF) on cutaneous scar quality after thyroidectomy. METHOD: Scar quality was evaluated by Vancouver scar scale (VSS) in two groups of female thyroidectomy patients (control, n = 11; rhEGF-treated, n = 10). Scar erythema, pigmentation, elasticity and hydration were measured by mexameter, cutometer and corneometer. RESULTS: Scar pliability (at 4 weeks) and thickness (2 weeks) after surgery were significantly lower in the rhEGF group than control. Total VSS score was significantly lower in the rhEGF group after 4 weeks. However, erythema, pigmentation, elasticity and hydration of the scar were not significantly different between groups. CONCLUSION: The early use of rhEGF in surgical wound healing may improve cutaneous scar quality.
Full Text
http://www.tandfonline.com/doi/abs/10.3109/09546634.2014.906034
DOI
10.3109/09546634.2014.906034
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139142
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