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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns

Authors
 S Yoon  ;  S J Park  ;  J H Han  ;  J H Kang  ;  J H Kim  ;  J Lee  ;  S Park  ;  H J Shin  ;  K Kim  ;  M Yun  ;  Y J Chwae 
Citation
 CELL DEATH & DISEASE, Vol.5 : 1494, 2014 
Journal Title
 CELL DEATH & DISEASE 
Issue Date
2014
MeSH
Amino Acids/deficiency ; Calpain/metabolism ; Caspases/metabolism* ; Cell Death ; Cell Line, Tumor ; Chloride Channels/metabolism ; DNA Damage* ; Deoxyribonucleases/metabolism ; Humans ; Models, Biological ; Nucleosomes/metabolism* ; Nucleosomes/ultrastructure ; Receptors, Pattern Recognition/metabolism*
Abstract
Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel combined mode of cellular demise--caspase-dependent regulated necrosis. Most importantly, it is mainly characterized with release of marked amount of oligo- or poly-nucleosomes and their attached damage-associated molecular patterns (DAMPs) and initiated by caspase activation. Caspase-activated DNase has dual roles in nucleosomal release as it can degrade extracellularly released chromatin into poly- or oligo-nucleosomes although it prohibits release of nucleosomes. In addition, osmotically triggered water movement following Cl(-) influx and subsequent Na(+) influx appears to be the major driving force for nucleosomal and DAMPs release. Finally, Ca(2+)-activated cysteine protease, calpain, is an another essential factor in nucleosomal and DAMPs release because of complete reversion to apoptotic morphology from necrotic one and blockade of nucleosomal and DAMPs release by its inhibition.
Full Text
http://www.nature.com/cddis/journal/v5/n10/full/cddis2014450a.html
DOI
10.1038/cddis.2014.450
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139093
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