287 446

Cited 5 times in

Accelerated and Exacerbated Effects of High Dietary Fat on Neuronal Damage Induced by Transient Cerebral Ischemia in the Gerbil Septum

DC Field Value Language
dc.contributor.author김민정-
dc.contributor.author박유석-
dc.date.accessioned2015-12-28T11:15:54Z-
dc.date.available2015-12-28T11:15:54Z-
dc.date.issued2014-
dc.identifier.issn2093-596X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139063-
dc.description.abstractBackground : Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little research regarding the effects of HFD-induced obesity in the septa of animal models of cerebral ischemia. Therefore, in the present study, we investigated septal effects of HFD on neuronal damage and gliosis induced by transient cerebral ischemia. Methods : Body weight, blood glucose levels and serum lipid profiles levels were measured both in the normal diet (ND) and HFD-group. We also investigated the effects of ND and HFD on neuronal damage and gliosis in the septum after transient cerebral ischemia using immunohistochemistry. Results : The levels of blood glucose, serum triglyceride, and total cholesterol were significantly increased in the HFD-fed gerbils compared with the ND-fed gerbils, although body weight was not significantly changed after HFD feeding. In the ND-fed gerbils, ischemia-induced neuronal damage was found in the septohippocampal nucleus (SHN) of the septum 7 days after ischemia. In the HFD-fed gerbils, ischemia-induced neuronal damage in the SHN was much more severe compared with that of the ND-fed gerbils 4 and 7 days after ischemia. In addition, we found that ischemia-induced glial activation including astrocytes and microglia was accelerated and exacerbated in the HFD-fed gerbils compared with that in the ND-fed gerbils. Conclusion : These results indicate that HFD can lead to much more severe effects in ischemia-induced neuronal damage/death in the septum after ischemia-reperfusion, and that it may be associated with accelerated change in glial activation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent328~335-
dc.relation.isPartOfEndocrinology and Metabolism (대한내분비학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAccelerated and Exacerbated Effects of High Dietary Fat on Neuronal Damage Induced by Transient Cerebral Ischemia in the Gerbil Septum-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학)-
dc.contributor.googleauthorSeung Hwan Cheon-
dc.contributor.googleauthorBing Chun Yan-
dc.contributor.googleauthorBai Hui Chen-
dc.contributor.googleauthorJoon Ha Park-
dc.contributor.googleauthorJi Hyeon Ahn-
dc.contributor.googleauthorIn Hye Kim-
dc.contributor.googleauthorJae Chul Lee-
dc.contributor.googleauthorYoo Seok Park-
dc.contributor.googleauthorMin Joung Kim-
dc.contributor.googleauthorYun Lyul Lee-
dc.contributor.googleauthorJun Hwi Cho-
dc.contributor.googleauthorMoo Ho Won-
dc.identifier.doi10.3803/EnM.2014.29.3.328-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00470-
dc.contributor.localIdA01592-
dc.relation.journalcodeJ00773-
dc.identifier.pmid25309792-
dc.subject.keywordDiet, high-fat-
dc.subject.keywordGlial activation-
dc.subject.keywordIschemic attack, transient-
dc.subject.keywordSeptohippocampal nucleus-
dc.contributor.alternativeNameKim, Min Joung-
dc.contributor.alternativeNamePark, Yoo Seok-
dc.contributor.affiliatedAuthorKim, Min Joung-
dc.contributor.affiliatedAuthorPark, Yoo Seok-
dc.citation.volume29-
dc.citation.number3-
dc.citation.startPage328-
dc.citation.endPage335-
dc.identifier.bibliographicCitationEndocrinology and Metabolism (대한내분비학회지), Vol.29(3) : 328-335, 2014-
dc.identifier.rimsid52459-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.