It is well known that external chest compression during cardiopulmonary resuscitation is frequently associated with variouscomplications. These complications predominantly involve trauma to the heart, lungs, and chest wall, whereas cases involving intra-abdominalinjury are much less frequent. The present report describes a rare case of a female patient with severe hemoperitoneum associatedwith liver injury after cardiopulmonary resuscitation. Although emergent angiography and embolization of the hepatic arterywere performed and transfusion of various kinds of blood products was done continuously, the patient expired the next day.