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Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome.

 Jin Ju Kim  ;  Kyu Ri Hwang  ;  Young Min Choi  ;  Shin Yong Moon  ;  Soo Jin Chae  ;  Chan Woo Park  ;  Hye Ok Kim  ;  Doo Seok Choi  ;  Hyuck Chan Kwon  ;  Byung Moon Kang  ;  Byung Seok Lee  ;  Si Hyun Cho  ;  Tai June Kim  ;  Tak Kim  ;  Min Ju Kim  ;  Hyun Young Park 
 FERTILITY AND STERILITY, Vol.101(5) : 1424-1430, 2014 
Journal Title
Issue Date
Adolescent ; Adult ; Asian Continental Ancestry Group/ethnology ; Asian Continental Ancestry Group/genetics* ; Cohort Studies ; Female ; Glucose Tolerance Test/trends ; Humans ; Insulin Resistance/physiology ; Metabolic Syndrome/ethnology ; Metabolic Syndrome/genetics ; Metabolic Syndrome/metabolism ; Metabolome/genetics* ; Metabolome/physiology ; Phenotype* ; Polycystic Ovary Syndrome/ethnology ; Polycystic Ovary Syndrome/genetics* ; Polycystic Ovary Syndrome/metabolism* ; Republic of Korea/ethnology ; Young Adult
Metabolic syndrome ; Rotterdam criteria ; phenotype ; polycystic ovary syndrome ; type 2 diabetes
OBJECTIVE: To investigate the complete metabolic and phenotypic profiles of a large cohort of untreated, consecutively recruited Korean women with polycystic ovary syndrome (PCOS), for whom a registry for Korean women with PCOS was constructed.
DESIGN: Observational study.
SETTING: Three infertility clinics and 10 university hospitals.
PATIENT(S): Eight hundred sixty-five women with PCOS were recruited using the Rotterdam criteria.
INTERVENTION(S): Standardized evaluation protocol and web-based case report form.
MAIN OUTCOME MEASURE(S): Metabolic and phenotypic profiles.
RESULT(S): The subjects with PCOS mainly consisted of young and nonobese women. The most problematic subjective symptom was menstrual disturbance or infertility, and, on average, the patients seemed to menstruate every 2 months. PCO morphology was observed in 96.5% of the patients. Although few women visited hospitals owing to HA symptoms alone, hirsutism was observed in one-third of the patients (33.9%) and half (47.4%) of the patients had biochemical HA. About one-fifth (20.1%) of the patients had generalized obesity, and one-third (33.2%) had central obesity. Prevalence of dyslipidemia, diabetes, hypertension, and metabolic syndrome were 35.7%, 3.5%, 4.0%, and 13.7%, respectively. Prevalence of prediabetes was 20.8%, and a substantial proportion of additional subjects with normal fasting plasma glucose or oral glucose tolerance tests were identified as having prediabetes by hemoglobin A1C testing.
CONCLUSION(S): Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to PCOS in Korean women. Further longitudinal follow-up studies are needed to investigate the changes in phenotypic and metabolic markers in this PCOS cohort.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
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