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Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical and BRAF Analysis.

Authors
 Ji Hye Park  ;  Hyeong Ju Kwon  ;  Cheong Soo Park  ;  Soon Won Hong 
Citation
 KOREAN JOURNAL OF PATHOLOGY , Vol.48(3) : 234-240, 2014 
Journal Title
 KOREAN JOURNAL OF PATHOLOGY 
ISSN
 1738-1843 
Issue Date
2014
Keywords
Immunohistochemistry ; Proto-oncogene proteins B-raf ; Thyroid cancer, anaplastic ; Young adult
Abstract
This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid transcription factor 1 (TTF-1), and galectin-3 expression than the well-differentiated area. However there was no increased p53 or Ki-67 expression in the poorly differentiated foci, nor in the well-differentiated area. The tissue subsequently relapsed and revealed only anaplastic features, complete loss of thyroglobulin, TTF-1, and galectin-3 expression and revealed an increase in p53 and Ki-67 expression. The BRAF V600E and BRAF V600V mutation were found in the initially diagnosed papillary thyroid carcinoma and the poorly differentiated foci of the recurring papillary thyroid carcinoma; however, only the BRAF V600V mutation was found in the anaplastic carcinoma. These results suggest that overexpression of p53 and Ki-67 contributed to the anaplastic transformation. We also found that the BRAF type changed during the tumor relapse.
Files in This Item:
T201405887.pdf Download
DOI
10.4132/KoreanJPathol.2014.48.3.234
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyeong Ju(권형주)
Park, Cheong Soo(박정수)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138991
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