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The fate of heterotopic ossification associated with cervical artificial disc replacement.

Authors
 Seong Yi  ;  Jaekeun Oh  ;  Gwihyun Choi  ;  Tae Yup Kim  ;  Hyun Chul Shin  ;  Keung Nyun Kim  ;  Keun Su Kim  ;  Do Heum Yoon 
Citation
 Spine, Vol.39(25) : 2078-2083, 2014 
Journal Title
 Spine 
ISSN
 0362-2436 
Issue Date
2014
Abstract
STUDY DESIGN: This is a retrospective study designed to observe the progressive appearance of heterotopic ossification (HO) after cervical artificial disc replacement (ADR). OBJECTIVE: To investigate the development and progressive appearance of HO at cervical ADR sites. SUMMARY OF BACKGROUND DATA: HO is defined as the formation of bone outside the skeletal system. The reported HO occurrence rate in cervical ADR is high and varied. However, the long-term outcome of HO has not been investigated by longitudinal observation. METHODS: Sixty-seven consecutive patients undergoing cervical ADR with complete radiological data were selected for this study. Cervical lateral radiographs and computed tomographic scans were obtained during the first and second studies and compared to identify any transitions in HO. The change in the HO occurrence rate, distribution, and grade of HO were investigated at 2 follow-up time points (18.6 and 36.9 mo postsurgery). To compare the amount of progression between participants' HO rates, the relative increase rate was calculated. RESULTS: HO showed a progressive pattern. The grade of HO was redistributed toward a higher grade in the second study. The number of patients with HO had increased from 31 (46.3%) to 43 (64.2%) of 67 patients at the final follow-up with statistically significant difference (P = 0.037). Twenty-six patients (39.4%) had progressed toward a higher HO grade, but 41 patients (60.6%) showed no change in HO grade. The overall RI rate and the weighted RI rate were 39.4% and 48.7%, respectively. CONCLUSION: This study found that HO has a progressive appearance and determined that HO is not a static but rather a dynamic phenomenon with progressive pattern. Future elucidation of the environmental factors affecting HO, including genetic or proteomic analyses, is recommended. LEVEL OF EVIDENCE: 3.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007632-201412010-00008&LSLINK=80&D=ovft
DOI
10.1097/BRS.0000000000000640
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
김근수(Kim, Keun Su)
김긍년(Kim, Keung Nyun)
김태엽(Kim, Tae Yup)
오재근(Oh, Jae Keun)
윤도흠(Yoon, Do Heum)
이성(Yi, Seong)
최귀현(Choi, Gwi Hyun)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138937
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