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Determination of optimal acquisition time of [(18)F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects

Authors
 Jae Yong Choi  ;  Minkyung Lee  ;  Tae Joo Jeon  ;  Soo-Hee Choi  ;  Ye Ji Choi  ;  Yu Kyung Lee  ;  Jae-Jin Kim  ;  Young Hoon Ryu 
Citation
 APPLIED RADIATION AND ISOTOPES, Vol.89 : 141-145, 2014 
Journal Title
 APPLIED RADIATION AND ISOTOPES 
ISSN
 0969-8043 
Issue Date
2014
MeSH
Adult ; Brain/diagnostic imaging* ; Brain/metabolism* ; Cyclohexanes*/pharmacokinetics ; Fluorine Radioisotopes ; Humans ; Image Processing, Computer-Assisted ; Male ; Piperazines*/pharmacokinetics ; Positron-Emission Tomography/methods* ; Radiopharmaceuticals*/pharmacokinetics ; Receptor, Serotonin, 5-HT1A/analysis* ; Receptor, Serotonin, 5-HT1A/metabolism
Keywords
5-HT(1A) receptors ; Optimal acquisition time ; PET ; [(18)F]FCWAY
Abstract
The purpose of this research is to find optimal acquisition time point of [(18)F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT1A) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90 min after injection and remained stable at 120 min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90 min p.i. is a better single time point for the analysis rather than previous time points for assessing [(18)F]FCWAY binding to 5-HT1A receptors.
Full Text
http://www.sciencedirect.com/science/article/pii/S0969804314000669
DOI
10.1016/j.apradiso.2014.02.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Min Kyung(이민경)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138888
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