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Prognostic value of neutrophil-to-lymphocyte ratio in patients treated with concurrent chemoradiotherapy for locally advanced oesophageal cancer

Authors
 Eun Jin Yoo  ;  Jun Chul Park  ;  Eun Hye Kim  ;  Chan Hyuk Park  ;  Choong Nam Shim  ;  Hyun Jik Lee  ;  Hyun Soo Chung  ;  Hyuk Lee  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Chang Geol Lee  ;  Yong Chan Lee 
Citation
 Digestive and Liver Disease, Vol.46(9) : 846-853, 2014 
Journal Title
 Digestive and Liver Disease 
ISSN
 1590-8658 
Issue Date
2014
Abstract
BACKGROUND: We performed a retrospective analysis of Asian patients with locally advanced oesophageal cancer to test the hypothesis that an elevated neutrophil-to-lymphocyte ratio is associated with a poor survival rate after definitive concurrent chemoradiotherapy. METHODS: In total, 138 patients diagnosed with locally advanced oesophageal cancer (TNM classification of malignant tumours stage II or III) who were treated with definitive concurrent chemoradiotherapy between January 2005 and December 2010 were retrospectively analysed. Definitive concurrent chemoradiotherapy was performed using two different chemotherapy regimens. RESULTS: The median follow-up duration was 39.5 months (range 1.1-93.4). The median progression-free survival was 14.0 months, and the median overall survival was 19.9 months. Compared with the low (<2.0) neutrophil-to-lymphocyte ratio group (n=43, 31.2%), the high (≥2.0) neutrophil-to-lymphocyte ratio group (n=95, 68.8%) exhibited significant decreases in the durations of both progression-free survival and overall survival. Using multivariate analysis, an elevated neutrophil-to-lymphocyte ratio was also significantly associated with decreased progression-free survival (HR 1.799; 95% CI, 1.050-3.083; P=0.032) and overall survival duration (HR 2.115; 95% CI, 1.193-3.749; P=0.010). CONCLUSIONS: The pretreatment neutrophil-to-lymphocyte ratio is a useful prognostic marker in patients with locally advanced oesophageal cancer treated with definitive concurrent chemoradiotherapy.
Full Text
http://www.sciencedirect.com/science/article/pii/S1590865814003673
DOI
10.1016/j.dld.2014.05.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김은혜(Kim, Eun Hye) ORCID logo https://orcid.org/0000-0001-6691-6837
박준철(Park, Jun Chul) ORCID logo https://orcid.org/0000-0001-8018-0010
박찬혁(Park, Chan Hyuk)
신성관(Shin, Sung Kwan)
심충남(Shim, Choong Nam)
유은진(Yoo, Eun Jin)
이상길(Lee, Sang Kil) ORCID logo https://orcid.org/0000-0002-0721-0364
이용찬(Lee, Yong Chan)
이창걸(Lee, Chang Geol) ORCID logo https://orcid.org/0000-0002-8702-881X
이혁(Lee, Hyuk)
이현직(Lee, Hyun Jik)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138876
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