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A comparison of risk factors for mortality from heart failure in Asian and non-Asian populations: an overview of individual participant data from 32 prospective cohorts from the Asia-Pacific Region

 Rachel R Huxley  ;  Federica Barzi  ;  Jean Woo  ;  Graham Giles  ;  Tai Hing Lam  ;  Kazem Rahimi  ;  Suma Konety  ;  Takayoshi Ohkubo  ;  Sun Ha Jee  ;  Xianghua Fang  ;  Mark Woodward  ;  and Asia Pacific Cohort Studies Collaboration 
 BMC CARDIOVASCULAR DISORDERS, Vol.14(61) : 1-10, 2014 
Journal Title
Issue Date
Adult ; Aged ; Asia/epidemiology ; Asian Continental Ancestry Group* ; Diabetes Mellitus/ethnology ; Diabetes Mellitus/mortality ; Female ; Heart Failure/ethnology* ; Heart Failure/mortality* ; Humans ; Hypertension/ethnology ; Hypertension/mortality ; Male ; Middle Aged ; Obesity/ethnology ; Obesity/mortality ; Prognosis ; Prospective Studies ; Risk Assessment ; Risk Factors ; Smoking/adverse effects ; Smoking/ethnology ; Smoking/mortality ; Time Factors
Meta-analysis ; Heart failure ; Epidemiology
BACKGROUND: Most of what is known regarding the epidemiology of mortality from heart failure (HF) comes from studies within Western populations with few data available from the Asia-Pacific region where the burden of heart failure is increasing. METHODS: Individual level data from 543694 (85% Asian; 36% female) participants from 32 cohorts in the Asia Pacific Cohort Studies Collaboration were included in the analysis. Adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality from HF were estimated separately for Asians and non-Asians for a quintet of cardiovascular risk factors: systolic blood pressure, diabetes, body mass index, cigarette smoking and total cholesterol. All analyses were stratified by sex and study. RESULTS: During 3,793,229 person years of follow-up there were 614 HF deaths (80% Asian). The positive associations between elevated blood pressure, obesity, and cigarette smoking were consistent for Asians and non-Asians. There was evidence to indicate that diabetes was a weaker risk factor for death from HF for Asians compared with non-Asians: HR 1.26 (95% CI: 0.74-2.13) versus 3.04 (95% CI 1.76-5.25) respectively; p for interaction = 0.022. Additional adjustment for covariates did not materially change the overall associations. There was no good evidence to indicate that total cholesterol was a risk factor for HF mortality in either population. CONCLUSIONS: Most traditional cardiovascular risk factors including elevated blood pressure, obesity and cigarette smoking appear to operate similarly to increase the risk of death from HF in Asians and non-Asians populations alike.
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4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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