Increasing carbapenem-resistant Gram-negative bacilli and decreasing metallo-β-lactamase producers over eight years from Korea.

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Authors: Yangsoon Lee ; Chang Ki Kim ; Hae Sun Chung ; Dongeun Yong ; Seok Hoon Jeong ; Kyungwon Lee ; Yunsop Chong

MeSH: Acinetobacter/classification ; Acinetobacter/drug effects ; Acinetobacter/enzymology* ; Acinetobacter Infections/drug therapy ; Anti-Bacterial Agents/pharmacology* ; Bacterial Proteins ; Carbapenems/pharmacology* ; Drug Resistance, Microbial ; Gram-Negative Bacteria/drug effects* ; Gram-Negative Bacteria/enzymology ; Gram-Negative Bacteria/isolation & purification ; Humans ; Incidence ; Microbial Sensitivity Tests/trends ; Population Surveillance ; Pseudomonas/classification ; Pseudomonas/drug effects ; Pseudomonas/enzymology ; Republic of Korea/epidemiology ; beta-Lactamases/biosynthesis ; beta-Lactamases/drug effects*

Abstract: The trends and types of carbapenemase-producing Gram-negative bacilli were analyzed from clinical specimens collected between 2005 and 2012 at a Korean teaching hospital. The proportions of carbapenem-resistant Acinetobacter spp. increased markedly to 66%. Metallo-β-lactamase producers significantly decreased and the majority shifted from the bla(VIM-2) type to the bla(IMP-1) type.