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Clinical characteristics of long-term survivors of inoperable pancreatic cancer: an 8-year cohort analysis in Korea.

 Jung Hyun Jo  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Seungmin Bang  ;  Seung Woo Park  ;  Jae Bock Chung  ;  Si Young Song 
 PANCREAS, Vol.43(7) : 1022-1031, 2014 
Journal Title
Issue Date
Aged ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Biomarkers, Tumor/blood ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Carcinoma, Pancreatic Ductal/blood ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/epidemiology* ; Carcinoma, Pancreatic Ductal/secondary ; Carcinoma, Pancreatic Ductal/therapy ; Chemoradiotherapy ; Combined Modality Therapy ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Disease-Free Survival ; Erlotinib Hydrochloride ; Female ; Fluorouracil/administration & dosage ; Humans ; Leucovorin/administration & dosage ; Male ; Middle Aged ; Organoplatinum Compounds/administration & dosage ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/epidemiology* ; Pancreatic Neoplasms/therapy ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/epidemiology ; Peritoneal Neoplasms/secondary ; Prognosis ; Proportional Hazards Models ; Quinazolines/administration & dosage ; Republic of Korea/epidemiology ; Retrospective Studies ; Survivors*/statistics & numerical data ; Treatment Outcome
locally advanced pancreatic cancer ; metastatic pancreatic cancer ; long-term survivor
OBJECTIVES: Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear.
METHODS: A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance Hospital between 2002 and 2009 were evaluated, who were selected statistically with a retrospective cohort study. They were divided into locally advanced pancreatic cancer (LAPC) and metastatic pancreatic cancer (MPC). Short-term survivors (SS group) were defined as patients who survived less than 9 months with LAPC and 6 months with MPC. Patients who survived 3 times longer than the SS group were classified as long-term survivors (LS group). Predictive factors of long-survival were identified by comparing the 2 groups, and effects of these factors on survival were investigated statistically.
RESULTS: In multivariate analysis, better performance status and lower CA19-9 were related to overall survival in LAPC. In MPC, younger age, better performance status, peritoneal metastasis, higher serum albumin, lower CA19-9, and CA19-9 variation were related to overall survival.
CONCLUSIONS: These parameters related to long-term survivors of advanced pancreatic cancer can be useful for the expectation of survival. In the near future, conjunction of these clinical factors and novel molecular biologic characteristics of individual patients can be used for the personalized therapy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Chung, Jae Bock(정재복)
Jo, Jung Hyun(조중현) ORCID logo https://orcid.org/0000-0002-2641-8873
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