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PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis.

DC Field Value Language
dc.contributor.author이종두-
dc.contributor.author조상래-
dc.date.accessioned2015-12-28T11:06:49Z-
dc.date.available2015-12-28T11:06:49Z-
dc.date.issued2014-
dc.identifier.issn1946-6234-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138720-
dc.description.abstractDefinitive clinical trials of new chemotherapies for treating tuberculosis (TB) require following subjects until at least 6 months after treatment discontinuation to assess for durable cure, making these trials expensive and lengthy. Surrogate endpoints relating to treatment failure and relapse are currently limited to sputum microbiology, which has limited sensitivity and specificity. We prospectively assessed radiographic changes using 2-deoxy-2-[(18)F]-fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) at 2 and 6 months (CT only) in a cohort of subjects with multidrug-resistant TB, who were treated with second-line TB therapy for 2 years and then followed for an additional 6 months. CT scans were read semiquantitatively by radiologists and were computationally evaluated using custom software to provide volumetric assessment of TB-associated abnormalities. CT scans at 6 months (but not 2 months) assessed by radiologist readers were predictive of outcomes, and changes in computed abnormal volumes were predictive of drug response at both time points. Quantitative changes in FDG uptake 2 months after starting treatment were associated with long-term outcomes. In this cohort, some radiologic markers were more sensitive than conventional sputum microbiology in distinguishing successful from unsuccessful treatment. These results support the potential of imaging scans as possible surrogate endpoints in clinical trials of new TB drug regimens. Larger cohorts confirming these results are needed.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfSCIENCE TRANSLATIONAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlgorithms-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHHumans-
dc.subject.MESHLung/diagnostic imaging-
dc.subject.MESHMale-
dc.subject.MESHMetronidazole/therapeutic use-
dc.subject.MESHMultimodal Imaging-
dc.subject.MESHObserver Variation-
dc.subject.MESHPositron-Emission Tomography*-
dc.subject.MESHProspective Studies-
dc.subject.MESHROC Curve-
dc.subject.MESHRadiographic Image Interpretation, Computer-Assisted-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSoftware-
dc.subject.MESHSputum/microbiology-
dc.subject.MESHTomography, X-Ray Computed*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTuberculosis, Multidrug-Resistant/diagnostic imaging*-
dc.subject.MESHTuberculosis, Multidrug-Resistant/therapy*-
dc.titlePET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorRay Y. Chen-
dc.contributor.googleauthorLori E. Dodd-
dc.contributor.googleauthorMyungsun Lee-
dc.contributor.googleauthorPraveen Paripati-
dc.contributor.googleauthorDima A. Hammoud-
dc.contributor.googleauthorJames M. Mountz-
dc.contributor.googleauthorDoosoo Jeon-
dc.contributor.googleauthorNadeem Zia-
dc.contributor.googleauthorHomeira Zahiri-
dc.contributor.googleauthorM. Teresa Coleman-
dc.contributor.googleauthorMatthew W. Carroll-
dc.contributor.googleauthorJong Doo Lee-
dc.contributor.googleauthorYeon Joo Jeong-
dc.contributor.googleauthorPeter Herscovitch-
dc.contributor.googleauthorSaher Lahouar-
dc.contributor.googleauthorMichael Tartakovsky-
dc.contributor.googleauthorAlexander Rosenthal-
dc.contributor.googleauthorSandeep Somaiyya-
dc.contributor.googleauthorSoyoung Lee-
dc.contributor.googleauthorLisa C. Goldfeder-
dc.contributor.googleauthorYing Cai-
dc.contributor.googleauthorLaura E. Via-
dc.contributor.googleauthorSeung Kyu Park-
dc.contributor.googleauthorSang Nae Cho-
dc.contributor.googleauthorClifton E. Barry III-
dc.identifier.doi10.1126/scitranslmed.3009501-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03138-
dc.contributor.localIdA03824-
dc.relation.journalcodeJ02645-
dc.identifier.eissn1946-6242-
dc.identifier.pmid25473034-
dc.identifier.urlhttp://stm.sciencemag.org/content/6/265/265ra166-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorCho, Sang Nae-
dc.rights.accessRightsfree-
dc.citation.volume6-
dc.citation.number265-
dc.citation.startPage265-
dc.citation.endPage166-
dc.identifier.bibliographicCitationSCIENCE TRANSLATIONAL MEDICINE, Vol.6(265) : 265-166, 2014-
dc.identifier.rimsid38802-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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