439 780

Cited 111 times in

The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis.

Authors
 Chan Hyuk Park  ;  Eun Hye Kim  ;  Yun Ho Roh  ;  Ha Yan Kim  ;  Sang Kil Lee 
Citation
 PLOS ONE, Vol.9(11) : e112558, 2014 
Journal Title
PLOS ONE
Issue Date
2014
MeSH
2-Pyridinylmethylsulfinylbenzimidazoles/adverse effects ; Dexlansoprazole/adverse effects ; Esomeprazole/adverse effects ; Humans ; Lansoprazole/adverse effects ; Magnesium/blood* ; Odds Ratio ; Omeprazole/adverse effects ; Proton Pump Inhibitors/adverse effects* ; Rabeprazole/adverse effects ; Risk Factors ; Treatment Outcome
Abstract
BACKGROUND: Although many case reports have described patients with proton pump inhibitor (PPI)-induced hypomagnesemia, the impact of PPI use on hypomagnesemia has not been fully clarified through comparative studies. We aimed to evaluate the association between the use of PPI and the risk of developing hypomagnesemia by conducting a systematic review with meta-analysis.
METHODS: We conducted a systematic search of MEDLINE, EMBASE, and the Cochrane Library using the primary keywords "proton pump," "dexlansoprazole," "esomeprazole," "ilaprazole," "lansoprazole," "omeprazole," "pantoprazole," "rabeprazole," "hypomagnesemia," "hypomagnesaemia," and "magnesium." Studies were included if they evaluated the association between PPI use and hypomagnesemia and reported relative risks or odds ratios or provided data for their estimation. Pooled odds ratios with 95% confidence intervals were calculated using the random effects model. Statistical heterogeneity was assessed with Cochran's Q test and I2 statistics.
RESULTS: Nine studies including 115,455 patients were analyzed. The median Newcastle-Ottawa quality score for the included studies was seven (range, 6-9). Among patients taking PPIs, the median proportion of patients with hypomagnesemia was 27.1% (range, 11.3-55.2%) across all included studies. Among patients not taking PPIs, the median proportion of patients with hypomagnesemia was 18.4% (range, 4.3-52.7%). On meta-analysis, pooled odds ratio for PPI use was found to be 1.775 (95% confidence interval 1.077-2.924). Significant heterogeneity was identified using Cochran's Q test (df = 7, P<0.001, I2 = 98.0%).
CONCLUSIONS: PPI use may increase the risk of hypomagnesemia. However, significant heterogeneity among the included studies prevented us from reaching a definitive conclusion.
Files in This Item:
T201405469.pdf Download
DOI
10.1371/journal.pone.0112558
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Eun Hye(김은혜) ORCID logo https://orcid.org/0000-0001-6691-6837
Kim, Ha Yan(김하얀)
Roh, Yun Ho(노윤호)
Park, Chan Hyuk(박찬혁)
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138687
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links