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Endoscopic resection for duodenal carcinoid tumors: A multicenter, retrospective study

Authors
 Gwang Ha Kim  ;  Jin Il Kim  ;  Seong Woo Jeon  ;  Jeong Seop Moon  ;  Il-Kwun Chung  ;  Sam-Ryong Jee  ;  Heung Up Kim  ;  Geom Seog Seo  ;  Gwang Ho Baik  ;  Yong Chan Lee  ;  The Korean College of Helicobacter and Upper Gastrointestinal Research 
Citation
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.29(1) : 318-324, 2014 
Journal Title
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 
ISSN
 0815-9319 
Issue Date
2014
MeSH
Adult ; Aged ; Carcinoid Tumor/pathology ; Carcinoid Tumor/surgery* ; Duodenal Neoplasms/surgery* ; Duodenoscopy/instrumentation ; Duodenoscopy/methods* ; Duodenum/pathology ; Duodenum/surgery ; Female ; Follow-Up Studies ; Humans ; Intestinal Mucosa*/pathology ; Intestinal Mucosa*/surgery ; Male ; Middle Aged ; Multicenter Studies as Topic ; Retrospective Studies ; Time Factors ; Treatment Outcome
Keywords
carcinoid tumor ; duodenum ; endoscopic resection
Abstract
BACKGROUND AND AIM: Gastrointestinal carcinoid tumors < 10 mm in diameter and limited to the submucosal layer demonstrate a low frequency of lymph node and distant metastasis, and are suitable for endoscopic treatment. The aim of this study was to assess the efficacy, safety, and long-term prognosis of endoscopic resections for the treatment of duodenal carcinoid tumors. METHODS: This study included a total of 41 duodenal carcinoid tumors in 38 patients between January 2006 and December 2011. The indications for endoscopic resection were lesions ≤ 10 mm in diameter, confined to the submucosal layer, and without lymph node or distant metastasis. Endoscopic resection was accomplished using endoscopic mucosal resection (EMR), EMR with a ligation device (EMR-L), EMR after circumferential precutting, or endoscopic submucosal dissection (ESD). RESULTS: EMR was performed in 18 tumors, EMR-L in 16, EMR after circumferential precutting in 3, and ESD in 4. En-bloc resection was performed in 39 tumors (95%), and endoscopic complete resection was achieved in 40 (98%); pathological complete resection was achieved in 17 tumors (41%). The endoscopic complete resection rate did not differ according to the resection method, but the pathological complete resection rate was higher for ESD than for EMR and EMR-L. Intraprocedural bleeding was noted in five cases, with no occurrence of perforation. Recurrence was not observed during the mean follow-up period of 17 months (range 1-53 months). CONCLUSION: Endoscopic resection appears to be a safe and effective treatment for duodenal carcinoid tumors measuring ≤ 10 mm in diameter and confined to the submucosal layer.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jgh.12390/abstract
DOI
10.1111/jgh.12390
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138638
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