0 282

Cited 7 times in

Limitation of the delta neutrophil index for assessing bacteraemia in immunocompromised children.

Authors
 Jong Gyun Ahn  ;  Seong Yeol Choi  ;  Dong Soo Kim  ;  Ki Hwan Kim 
Citation
 CLINICA CHIMICA ACTA, Vol.436 : 319-322, 2014 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2014
MeSH
Bacteremia/diagnosis* ; Bacteremia/immunology* ; Child ; Child, Preschool ; Female ; Humans ; Immunocompetence ; Immunocompromised Host* ; Infant ; Male ; Neutrophils/cytology*
Keywords
Bacteraemia ; Children ; Delta neutrophil index ; Immunocompromised
Abstract
BACKGROUND: Delta neutrophil index (DNI) has been reported to be useful in assessing the prognosis of suspected bacteraemia in adults. However, data in children are limited. The purpose of this study was to investigate the correlation between the DNI and bacteraemia in children and to compare DNI values between immunocompetent and immunocompromised hosts. METHODS: We retrospectively collected data on 8593 children who underwent simultaneous blood culture and DNI testing. DNI was determined with a blood cell analyser (ADVIA 120, Siemens, Inc.). The children were divided into immunocompromised (n=664) and immunocompetent groups (n=7929). RESULTS: DNI was higher in the bacteraemia group than in the non-bacteraemia group (P<0.001). According to the group, DNI was higher in immunocompromised than immunocompetent patients (P<0.001). Within the immunocompromised group, there was no significant difference between the bacteraemia and non-bacteraemia subgroups due to a higher DNI as compared to the immunocompetent group. CONCLUSIONS: DNI could be an additional method for the early diagnosis of bacteraemia in children. However, the use of DNI for the prediction of bacteraemia in immunocompromised cases has limitations. Further studies on the usefulness of DNI according to specific diseases are needed.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898114002782
DOI
10.1016/j.cca.2014.06.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
Ahn, Jong Gyun(안종균) ORCID logo https://orcid.org/0000-0001-5748-0015
Choi, Seong Yeol(최성열)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138527
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse