415 471

Cited 12 times in

Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice

DC Field Value Language
dc.contributor.author김자경-
dc.contributor.author이관식-
dc.contributor.author이동기-
dc.contributor.author이수연-
dc.contributor.author이정일-
dc.contributor.author장혜영-
dc.date.accessioned2015-12-28T11:00:10Z-
dc.date.available2015-12-28T11:00:10Z-
dc.date.issued2014-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138483-
dc.description.abstractNonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to alleviate experimental NASH, although its beneficial effect was not evident when tested clinically. Thus, this study aimed to investigate the additive effect of omega-3 and ursodeoxycholic acid (UDCA) on diet-induced NASH in mice. C57BL/6 mice were given a high-fat diet (HFD) for 24 weeks, at which point the mice were divided into three groups and fed HFD alone, HFD with omega-3 or HFD with omega-3 in combination with UDCA for another 24 weeks. Feeding mice an HFD and administering omega-3 improved histologically assessed liver fibrosis, and UDCA in combination with omega-3 further attenuated this disease. The assessment of collagen α1(I) expression agreed with the histological evaluation. Omega-3 in combination with UDCA resulted in a significant attenuation of inflammation whereas administering omega-3 alone failed to improve histologically assessed liver inflammation. Quantitative analysis of tumor necrosis factor α showed an additive effect of omega-3 and UDCA on liver inflammation. HFD-induced hepatic triglyceride accumulation was attenuated by omega-3 and adding UDCA accentuated this effect. In accordance with this result, the expression of sterol regulatory binding protein-1c decreased after omega-3 administration and adding UDCA further diminished SREBP-1c expression. The expression of inducible nitric oxide synthase (iNOS), which may reflect oxidative stress-induced tissue damage, was suppressed by omega-3 administration and adding UDCA further attenuated iNOS expression. These results demonstrated an additive effect of omega-3 and UDCA for alleviating fibrosis, inflammation and steatosis in diet-induced NASH.-
dc.description.statementOfResponsibilityopen-
dc.format.extente127-
dc.relation.isPartOfEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCholagogues and Choleretics/pharmacology-
dc.subject.MESHCholagogues and Choleretics/therapeutic use*-
dc.subject.MESHDiet, High-Fat/adverse effects-
dc.subject.MESHDrug Synergism-
dc.subject.MESHFatty Acids, Omega-3/pharmacology-
dc.subject.MESHFatty Acids, Omega-3/therapeutic use*-
dc.subject.MESHFibrosis/drug therapy-
dc.subject.MESHFibrosis/etiology-
dc.subject.MESHFibrosis/immunology-
dc.subject.MESHFibrosis/pathology-
dc.subject.MESHInflammation/drug therapy-
dc.subject.MESHInflammation/etiology-
dc.subject.MESHInflammation/immunology-
dc.subject.MESHInflammation/pathology-
dc.subject.MESHLiver/drug effects*-
dc.subject.MESHLiver/immunology-
dc.subject.MESHLiver/pathology-
dc.subject.MESHMale-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/drug therapy*-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/etiology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/immunology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/pathology-
dc.subject.MESHUrsodeoxycholic Acid/pharmacology-
dc.subject.MESHUrsodeoxycholic Acid/therapeutic use*-
dc.titleOmega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorDong Ki Lee-
dc.contributor.googleauthorSu Yeon Lee-
dc.contributor.googleauthorHye Young Chang-
dc.contributor.googleauthorJunjeong Choi-
dc.contributor.googleauthorJung Il Lee-
dc.identifier.doi10.1038/emm.2014.90-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00852-
dc.contributor.localIdA02666-
dc.contributor.localIdA02723-
dc.contributor.localIdA02890-
dc.contributor.localIdA03495-
dc.contributor.localIdA03122-
dc.relation.journalcodeJ00860-
dc.identifier.eissn2092-6413-
dc.identifier.pmid25523099-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameLee, Dong Ki-
dc.contributor.alternativeNameLee, Su Yeon-
dc.contributor.alternativeNameLee, Jung Il-
dc.contributor.alternativeNameChang, Hye Young-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorLee, Dong Ki-
dc.contributor.affiliatedAuthorLee, Su Yeon-
dc.contributor.affiliatedAuthorChang, Hye Young-
dc.contributor.affiliatedAuthorLee, Jung Il-
dc.citation.volume46-
dc.citation.startPage127-
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, Vol.46 : 127, 2014-
dc.identifier.rimsid45341-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.