Cited 20 times in
Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice
DC Field | Value | Language |
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dc.contributor.author | 김자경 | - |
dc.contributor.author | 이관식 | - |
dc.contributor.author | 이동기 | - |
dc.contributor.author | 이수연 | - |
dc.contributor.author | 이정일 | - |
dc.contributor.author | 장혜영 | - |
dc.date.accessioned | 2015-12-28T11:00:10Z | - |
dc.date.available | 2015-12-28T11:00:10Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138483 | - |
dc.description.abstract | Nonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to alleviate experimental NASH, although its beneficial effect was not evident when tested clinically. Thus, this study aimed to investigate the additive effect of omega-3 and ursodeoxycholic acid (UDCA) on diet-induced NASH in mice. C57BL/6 mice were given a high-fat diet (HFD) for 24 weeks, at which point the mice were divided into three groups and fed HFD alone, HFD with omega-3 or HFD with omega-3 in combination with UDCA for another 24 weeks. Feeding mice an HFD and administering omega-3 improved histologically assessed liver fibrosis, and UDCA in combination with omega-3 further attenuated this disease. The assessment of collagen α1(I) expression agreed with the histological evaluation. Omega-3 in combination with UDCA resulted in a significant attenuation of inflammation whereas administering omega-3 alone failed to improve histologically assessed liver inflammation. Quantitative analysis of tumor necrosis factor α showed an additive effect of omega-3 and UDCA on liver inflammation. HFD-induced hepatic triglyceride accumulation was attenuated by omega-3 and adding UDCA accentuated this effect. In accordance with this result, the expression of sterol regulatory binding protein-1c decreased after omega-3 administration and adding UDCA further diminished SREBP-1c expression. The expression of inducible nitric oxide synthase (iNOS), which may reflect oxidative stress-induced tissue damage, was suppressed by omega-3 administration and adding UDCA further attenuated iNOS expression. These results demonstrated an additive effect of omega-3 and UDCA for alleviating fibrosis, inflammation and steatosis in diet-induced NASH. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e127 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cholagogues and Choleretics/pharmacology | - |
dc.subject.MESH | Cholagogues and Choleretics/therapeutic use* | - |
dc.subject.MESH | Diet, High-Fat/adverse effects | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Fatty Acids, Omega-3/pharmacology | - |
dc.subject.MESH | Fatty Acids, Omega-3/therapeutic use* | - |
dc.subject.MESH | Fibrosis/drug therapy | - |
dc.subject.MESH | Fibrosis/etiology | - |
dc.subject.MESH | Fibrosis/immunology | - |
dc.subject.MESH | Fibrosis/pathology | - |
dc.subject.MESH | Inflammation/drug therapy | - |
dc.subject.MESH | Inflammation/etiology | - |
dc.subject.MESH | Inflammation/immunology | - |
dc.subject.MESH | Inflammation/pathology | - |
dc.subject.MESH | Liver/drug effects* | - |
dc.subject.MESH | Liver/immunology | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/drug therapy* | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/etiology | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/immunology | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/pathology | - |
dc.subject.MESH | Ursodeoxycholic Acid/pharmacology | - |
dc.subject.MESH | Ursodeoxycholic Acid/therapeutic use* | - |
dc.title | Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Ja Kyung Kim | - |
dc.contributor.googleauthor | Kwan Sik Lee | - |
dc.contributor.googleauthor | Dong Ki Lee | - |
dc.contributor.googleauthor | Su Yeon Lee | - |
dc.contributor.googleauthor | Hye Young Chang | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Jung Il Lee | - |
dc.identifier.doi | 10.1038/emm.2014.90 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A02723 | - |
dc.contributor.localId | A02890 | - |
dc.contributor.localId | A03495 | - |
dc.contributor.localId | A03122 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 25523099 | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.alternativeName | Lee, Dong Ki | - |
dc.contributor.alternativeName | Lee, Su Yeon | - |
dc.contributor.alternativeName | Lee, Jung Il | - |
dc.contributor.alternativeName | Chang, Hye Young | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Lee, Dong Ki | - |
dc.contributor.affiliatedAuthor | Lee, Su Yeon | - |
dc.contributor.affiliatedAuthor | Chang, Hye Young | - |
dc.contributor.affiliatedAuthor | Lee, Jung Il | - |
dc.citation.volume | 46 | - |
dc.citation.startPage | 127 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.46 : 127, 2014 | - |
dc.identifier.rimsid | 45341 | - |
dc.type.rims | ART | - |
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