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NT-proBNP: is it a more significant risk factor for mortality than troponin T in incident hemodialysis patients?

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author박정탁-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author이혜선-
dc.contributor.author한승혁-
dc.date.accessioned2015-12-28T10:59:43Z-
dc.date.available2015-12-28T10:59:43Z-
dc.date.issued2014-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138467-
dc.description.abstractNumerous studies have demonstrated that cardiac biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or measured 1 or 2 biomarkers. This study was to analyze the association between 3 cardiac biomarkers and mortality in incident HD patients. A prospective cohort of 864 incident HD patients was followed for 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patients were divided into "high" and "low" groups, and CV and all-cause mortality were compared between each group. Additionally, time-dependent ROC curves were constructed, and the NRI and IDI of the models with various biomarkers were calculated. The CV survival rates were significantly lower in the "high" NT-proBNP and cTnT groups compared to the corresponding "low" groups, while there was no significant difference in CV survival rate between the 2 hsCRP groups. However, all-cause mortality rates were significantly higher in all 3 "high" groups compared to each lower group. In multivariate analyses, only Ln NT-proBNP was found to be an independent predictor of mortality. Moreover, NT-proBNP was a more prognostic marker for mortality compared to cTnT. In conclusion, NT-proBNP is the biomarker that results in the most added prognostic value on top of traditional risk factors for CV and all-cause mortality in incident HD patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extente241~e241-
dc.relation.isPartOfMedicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNT-proBNP: is it a more significant risk factor for mortality than troponin T in incident hemodialysis patients?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorc-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae Hyun Yoo-
dc.contributor.googleauthorYong Lim Kim-
dc.contributor.googleauthorYon Su Kim-
dc.contributor.googleauthorChul Woo Yang-
dc.contributor.googleauthorNam Ho Kim-
dc.contributor.googleauthorShin Wook Kang-
dc.identifier.doi10.1097/MD.0000000000000241-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA01654-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA04304-
dc.contributor.localIdA03312-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02214-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.identifier.localIdT201404646-
dc.citation.volume93-
dc.citation.number27-
dc.citation.startPage241-
dc.citation.endPage241-
dc.identifier.bibliographicCitationMedicine, Vol.93(27) : 241-241, 2014-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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