Cited 2 times in
Clinical application of the fibrillation number in patients with an implantable cardioverter defibrillator
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.contributor.author | 이영선 | - |
dc.contributor.author | 이한철 | - |
dc.contributor.author | 황민기 | - |
dc.date.accessioned | 2015-12-28T10:59:32Z | - |
dc.date.available | 2015-12-28T10:59:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0079-6107 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138461 | - |
dc.description.abstract | INTRODUCTION: Although ventricular tachycardia/fibrillation (VT/VF) develops suddenly with catastrophic results, its prediction is limited. We tested the fibrillation number (FibN) for potential predictor of VT/VF using clinical data of implantable cardioverter-defibrillator (ICD) patients after validating the number by computational modeling. METHODS: For clinical application of FibN, we used electrocardiography and echocardiography data: QRS width, QTc, and left ventricular (LV) end-systolic dimension (FibNVT/VF1) or LV end-diastolic dimension (FibNVT/VF2). We compared the maintenance duration of VT/VF for various FibN values using computational modeling, and tested FibNVT/VF in 142 patients with ICD for secondary prevention and 426 patients in age-sex matched control group (81.9% male, 56.1 ± 12.3 years old). RESULTS: 1. Computational results showed a positive correlation between VT/VF maintenance duration and FibN (R = 0.82, p < 0.001). 2. FibNVT/VFs were significantly higher in patients with ICD than in control (both FibNVT/VF1 and FibNVT/VF2, p < 0.001). 3. Within ICD group, FibNVT/VF values were higher in patients with cardiomyopathy than those without (both FibNVT/VF1 and FibNVT/VF2, p < 0.001). 4. During 50 ± 39 months follow-up period, the frequency of appropriate ICD therapy was higher in the high FibNVT/VF group (FibNVT/VF1, p = 0.001; FibNVT/VF2, p = 0.002). Both FibNVT/VF1 (HR 2.51, 95%CI 1.48-4.24, p = 0.001) and FibNVT/VF2 (HR 2.11, 95%CI 1.25-3.55, p = 0.005) were independently associated with appropriate ICD therapy in multi-variate analyses. CONCLUSION: FibNVT/VF, a parameter based on wavelength and heart size, correlates well with maintenance of VT/VF in computational modeling, and may have predictive value for VT/VF events in patients with ICD for secondary prevention. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33~39 | - |
dc.relation.isPartOf | PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | Defibrillators, Implantable* | - |
dc.subject.MESH | Diagnosis, Computer-Assisted/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Conduction System/physiopathology* | - |
dc.subject.MESH | Heart Ventricles/physiopathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models, Cardiovascular* | - |
dc.subject.MESH | Patient-Specific Modeling | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Therapy, Computer-Assisted/methods | - |
dc.subject.MESH | Ventricular Fibrillation/diagnosis | - |
dc.subject.MESH | Ventricular Fibrillation/physiopathology* | - |
dc.subject.MESH | Ventricular Fibrillation/prevention & control* | - |
dc.title | Clinical application of the fibrillation number in patients with an implantable cardioverter defibrillator | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Minki Hwang | - |
dc.contributor.googleauthor | Hancheol Lee | - |
dc.contributor.googleauthor | Young-Seon Lee | - |
dc.contributor.googleauthor | Soonwon Chung | - |
dc.contributor.googleauthor | Sung Hwan Choi | - |
dc.contributor.googleauthor | Eun Bo Shim | - |
dc.contributor.googleauthor | Hui-Nam Paka, | - |
dc.identifier.doi | 10.1016/j.pbiomolbio.2014.09.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02957 | - |
dc.contributor.localId | A03280 | - |
dc.contributor.localId | A04459 | - |
dc.relation.journalcode | J02552 | - |
dc.identifier.eissn | 1873-1732 | - |
dc.identifier.pmid | 25236363 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0079610714000935 | - |
dc.subject.keyword | Arrhythmogenecity | - |
dc.subject.keyword | Computational modeling | - |
dc.subject.keyword | Implantable cardioverter defibrillator | - |
dc.subject.keyword | Ventricular fibrillation | - |
dc.subject.keyword | Ventricular tachycardia | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Lee, Young Seon | - |
dc.contributor.alternativeName | Lee, Han Cheol | - |
dc.contributor.alternativeName | Hwang, Min Ki | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Lee, Young Seon | - |
dc.contributor.affiliatedAuthor | Lee, Han Cheol | - |
dc.contributor.affiliatedAuthor | Hwang, Min Ki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 116 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 39 | - |
dc.identifier.bibliographicCitation | PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, Vol.116(1) : 33-39, 2014 | - |
dc.identifier.rimsid | 45327 | - |
dc.type.rims | ART | - |
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